Exhibit 99.1 This Statement on Form 4 is filed by the Reporting Persons listed below. Name of Designated Filer: ARTAL INTERNATIONAL S.C.A. Date of Event Requiring Statement: August 5, 2022. Issuer Name: Lexicon Pharmaceuticals, Inc. [LXRX] ARTAL INTERNATIONAL S.C.A. By: Artal International Management S.A., its managing partner By: /s/ Anne Goffard ------------------------------- Name: Anne Goffard Title: Managing Director ARTAL INTERNATIONAL MANAGEMENT S.A. By: /s/ Anne Goffard ------------------------------- Name: Anne Goffard Title: Managing Director ARTAL GROUP S.A. By: /s/ Anne Goffard ------------------------------- Name: Anne Goffard Title: Authorized Person WESTEND S.A. By: /s/ Anne Goffard ------------------------------- Name: Anne Goffard Title: Managing Director STICHTING ADMINISTRATIEKANTOOR WESTEND By: /s/ Amaury Wittouck -------------------- Name: Amaury Wittouck Title: Sole Member of the Board AMAURY WITTOUCK By: /s/ Amaury Wittouck ------------------- INVUS, L.P. By: INVUS ADVISORS, L.L.C., its general partner By: /s/ Raymond Debbane ------------------- Name: Raymond Debbane Title: President INVUS PUBLIC EQUITIES, L.P. By: INVUS PUBLIC EQUITIES ADVISORS, LLC, its general partner By: /s/ Raymond Debbane ------------------- Name: Raymond Debbane Title: President INVUS ADVISORS, L.L.C. By: /s/ Raymond Debbane ------------------- Name: Raymond Debbane Title: President INVUS PUBLIC EQUITIES ADVISORS, LLC By: /s/ Raymond Debbane ------------------- Name: Raymond Debbane Title: President