XML 50 R36.htm IDEA: XBRL DOCUMENT v3.7.0.1
Organization and Significant Accounting Policies - Additional Information (Detail)
3 Months Ended 12 Months Ended
Dec. 31, 2016
USD ($)
Financial_Institution
Sep. 30, 2016
USD ($)
Jun. 30, 2016
USD ($)
Mar. 31, 2016
USD ($)
Dec. 31, 2015
USD ($)
Sep. 30, 2015
USD ($)
Jun. 30, 2015
USD ($)
Mar. 31, 2015
USD ($)
Dec. 31, 2016
USD ($)
Financial_Institution
Segment
Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Summary Of Significant Accounting Policies [Line Items]                      
Accumulated deficit incurred $ (518,291,000)       $ (534,744,000)       $ (518,291,000) $ (534,744,000)  
Net income 7,157,000 $ 33,362,000 $ (11,611,000) $ (12,455,000) (9,229,000) $ (8,849,000) $ (10,551,000) $ (8,872,000) 16,453,000 (37,501,000) $ (14,646,000)
Net cash provided by (used in) operating activities                 36,982,000 4,883,000 $ (44,843,000)
Cash, cash equivalents and investments $ 163,900,000       111,600,000       $ 163,900,000 $ 111,600,000  
Cash requirements term                 12 months    
Number of major financial institutions | Financial_Institution 3               3    
Percentage of income tax likely to be realized                 50.00%    
Number of reporting segment | Segment                 1    
Computer Equipment and Software [Member]                      
Summary Of Significant Accounting Policies [Line Items]                      
Property and equipment estimated useful lives                 3 years    
Laboratory Equipment and Office Equipment [Member]                      
Summary Of Significant Accounting Policies [Line Items]                      
Property and equipment estimated useful lives                 5 years    
Furniture and Fixtures [Member]                      
Summary Of Significant Accounting Policies [Line Items]                      
Property and equipment estimated useful lives                 7 years    
Leasehold Improvements [Member] | Maximum [Member]                      
Summary Of Significant Accounting Policies [Line Items]                      
Property and equipment estimated useful lives                 7 years    
Leasehold Improvements [Member] | Minimum [Member]                      
Summary Of Significant Accounting Policies [Line Items]                      
Property and equipment estimated useful lives                 3 years    
United States [Member] | Geographic Concentration Risk [Member] | Sales Revenue, Net [Member]                      
Summary Of Significant Accounting Policies [Line Items]                      
Revenues derived                 27.00% 9.00% 10.00%
Japanese [Member] | Geographic Concentration Risk [Member] | Sales Revenue, Net [Member]                      
Summary Of Significant Accounting Policies [Line Items]                      
Revenues derived                 73.00% 91.00% 90.00%
Amgen [Member]                      
Summary Of Significant Accounting Policies [Line Items]                      
Accounts receivable due $ 0       0       $ 0 $ 0  
Amgen [Member] | Customer Concentration Risk [Member] | Sales Revenue, Net [Member]                      
Summary Of Significant Accounting Policies [Line Items]                      
Revenues derived                 26.00% 9.00% 10.00%
Astellas [Member]                      
Summary Of Significant Accounting Policies [Line Items]                      
Accounts receivable due $ 0       $ 0       $ 0 $ 0  
Astellas [Member] | Customer Concentration Risk [Member] | Sales Revenue, Net [Member]                      
Summary Of Significant Accounting Policies [Line Items]                      
Revenues derived                 73.00% 91.00% 90.00%