Exhibit 22.1

List of Issuers of Debt Securities Guaranteed by Enterprise Products Partners L.P. and Associated Securities at June 30, 2021.

In compliance with Item 601(b)(22) of Regulation S-K, the following is a list of publicly traded debt securities issued by Enterprise Products Operating LLC (the “Subsidiary Issuer”) and guaranteed by Enterprise Products Partners L.P. (the “Parent Guarantor”) (dollars in millions):

   
Amounts Outstanding at
 
Guaranteed Securities
 
June 30, 2021
 
Senior Notes VV, 3.50% fixed-rate, due February 2022
 
$
750.0
 
Senior Notes CC, 4.05% fixed-rate, due February 2022
   
650.0
 
Senior Notes HH, 3.35% fixed-rate, due March 2023
   
1,250.0
 
Senior Notes JJ, 3.90% fixed-rate, due February 2024
   
850.0
 
Senior Notes MM, 3.75% fixed-rate, due February 2025
   
1,150.0
 
Senior Notes PP, 3.70% fixed-rate, due February 2026
   
875.0
 
Senior Notes SS, 3.95% fixed-rate, due February 2027
   
575.0
 
Senior Notes WW, 4.15% fixed-rate, due October 2028
   
1,000.0
 
Senior Notes YY, 3.125% fixed-rate, due July 2029
   
1,250.0
 
Senior Notes AAA, 2.80% fixed-rate, due January 2030
   
1,250.0
 
Senior Notes D, 6.875% fixed-rate, due March 2033
   
500.0
 
Senior Notes H, 6.65% fixed-rate, due October 2034
   
350.0
 
Senior Notes J, 5.75% fixed-rate, due March 2035
   
250.0
 
Senior Notes W, 7.55% fixed-rate, due April 2038
   
399.6
 
Senior Notes R, 6.125% fixed-rate, due October 2039
   
600.0
 
Senior Notes Z, 6.45% fixed-rate, due September 2040
   
600.0
 
Senior Notes BB, 5.95% fixed-rate, due February 2041
   
750.0
 
Senior Notes DD, 5.70% fixed-rate, due February 2042
   
600.0
 
Senior Notes EE, 4.85% fixed-rate, due August 2042
   
750.0
 
Senior Notes GG, 4.45% fixed-rate, due February 2043
   
1,100.0
 
Senior Notes II, 4.85% fixed-rate, due March 2044
   
1,400.0
 
Senior Notes KK, 5.10% fixed-rate, due February 2045
   
1,150.0
 
Senior Notes QQ, 4.90% fixed-rate, due May 2046
   
975.0
 
Senior Notes UU, 4.25% fixed-rate, due February 2048
   
1,250.0
 
Senior Notes XX, 4.80% fixed-rate, due February 2049
   
1,250.0
 
Senior Notes ZZ, 4.20% fixed-rate, due January 2050
   
1,250.0
 
Senior Notes BBB, 3.70% fixed-rate, due January 2051
   
1,000.0
 
Senior Notes DDD, 3.20% fixed-rate, due February 2052
   
1,000.0
 
Senior Notes NN, 4.95% fixed-rate, due October 2054
   
400.0
 
Senior Notes CCC, 3.95% fixed rate, due January 2060
   
1,000.0
 
Junior Subordinated Notes C, variable-rate, due June 2067
   
232.2
 
Junior Subordinated Notes D, fixed/variable-rate, due August 2077
   
700.0
 
Junior Subordinated Notes E, fixed/variable-rate, due August 2077
   
1,000.0
 
Junior Subordinated Notes F, fixed/variable-rate, due February 2078
   
700.0