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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001144204-08-032673.txt : 20080529
<SEC-HEADER>0001144204-08-032673.hdr.sgml : 20080529
<ACCEPTANCE-DATETIME>20080529160328
ACCESSION NUMBER:		0001144204-08-032673
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20080527
FILED AS OF DATE:		20080529
DATE AS OF CHANGE:		20080529

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GENEREX BIOTECHNOLOGY CORP
		CENTRAL INDEX KEY:			0001059784
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				820490211
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0731

	BUSINESS ADDRESS:	
		STREET 1:		33 HARBOUR SQ
		STREET 2:		STE 202
		CITY:			TORONTO ONTARIO CANADA
		STATE:			A1
		ZIP:			M5J 2G2
		BUSINESS PHONE:		4163642551

	MAIL ADDRESS:	
		STREET 1:		33 HARBOUR SQ
		STREET 2:		STE 202
		CITY:			TORONTO ONTARIO CA
		STATE:			A1
		ZIP:			M5J 2G2

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			GLUSKIN ANNA E
		CENTRAL INDEX KEY:			0001125857

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-25169
		FILM NUMBER:		08866593

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		4163642551

	MAIL ADDRESS:	
		STREET 1:		33 HARBOUR SQUARE STE 202
		CITY:			TORONTO
		STATE:			A6
		ZIP:			M5H2G2
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>v116089_ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2008-05-27</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001059784</issuerCik>
        <issuerName>GENEREX BIOTECHNOLOGY CORP</issuerName>
        <issuerTradingSymbol>GNBT</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001125857</rptOwnerCik>
            <rptOwnerName>GLUSKIN ANNA E</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>33 HARBOUR SQUARE, SUITE 202</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>TORONTO</rptOwnerCity>
            <rptOwnerState>A6</rptOwnerState>
            <rptOwnerZipCode>A1 M5H2G2</rptOwnerZipCode>
            <rptOwnerStateDescription>ONTARIO, CANADA</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>President &amp; CEO</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Stock Options (rights to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.96</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2008-05-27</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>50000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2008-05-27</value>
                <footnoteId id="F2"/>
            </exerciseDate>
            <expirationDate>
                <value>2013-05-27</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>50000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>50000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">On May 27, 2008, the Board of Directors of the issuer granted the reporting person options to purchase 50,000 shares of the
 issuer's common stock with an exercise price equal to the closing trading price of the issuer's common stock on the NASDAQ
 Capital Market on the date of grant (May 27,2008).  The grant was made pursuant to the terms of the issuer's 2006 Stock
 Plan.</footnote>
        <footnote id="F2">The options vest as follows:  50% of the options are exercisable on the date of grant; 25% of the options become exercisable
 on the first anniversary of the date of grant, and the remaining 25% of the options become exercisable on the second
 anniversary of the date of grant.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Anna E. Gluskin</signatureName>
        <signatureDate>2008-05-29</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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