The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | |||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | ||||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | (to the nearest dollar) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 4D MOLECULAR THERAPEUTICS IN | COM | 35104E100 | 124,968,078 | 3,922,413 | SH | DFND | 1 | 0 | 3,922,413 | 0 | ||
| 89BIO INC | COM | 282559103 | 47,111,201 | 4,047,354 | SH | DFND | 1 | 0 | 4,047,354 | 0 | ||
| AC IMMUNE SA | SHS | H00263105 | 43,130,859 | 14,571,236 | SH | DFND | 1 | 0 | 14,571,236 | 0 | ||
| ALLAKOS INC | COM | 01671P100 | 20,856,045 | 16,552,417 | SH | DFND | 1 | 0 | 16,552,417 | 0 | ||
| AN2 THERAPEUTICS INC | COM | 037326105 | 4,028,278 | 1,239,470 | SH | DFND | 1 | 0 | 1,239,470 | 0 | ||
| ANNEXON INC | COM | 03589W102 | 50,190,000 | 7,000,000 | SH | DFND | 1 | 0 | 7,000,000 | 0 | ||
| ASLAN PHARMACEUTICALS LTD | SPON ADS NEW | 04522R200 | 645,959 | 1,049,999 | SH | DFND | 1 | 0 | 1,049,999 | 0 | ||
| CALLIDITAS THERAPEUTICS AB | SPONSERED ADS | 13124Q106 | 16,237,500 | 750,000 | SH | DFND | 1 | 0 | 750,000 | 0 | ||
| CG ONCOLOGY INC | COM | 156944100 | 82,715,985 | 1,884,191 | SH | DFND | 1 | 0 | 1,884,191 | 0 | ||
| CIDARA THERAPEUTICS INC | COM | 171757107 | 6,312,237 | 6,861,127 | SH | DFND | 1 | 0 | 6,861,127 | 0 | ||
| CORVUS PHARMACEUTICALS INC | COM | 221015100 | 643,303 | 361,406 | SH | DFND | 1 | 0 | 361,406 | 0 | ||
| CULLINAN ONCOLOGY INC | COM | 230031106 | 54,471,785 | 3,196,701 | SH | DFND | 1 | 0 | 3,196,701 | 0 | ||
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 14,378,846 | 6,595,801 | SH | DFND | 1 | 0 | 6,595,801 | 0 | ||
| DELCATH SYS INC | COM NEW | 24661P807 | 5,733,860 | 1,202,067 | SH | DFND | 1 | 0 | 1,202,067 | 0 | ||
| ELEDON PHARMACEUTICALS INC | COM | 28617K101 | 8,913,023 | 4,326,710 | SH | DFND | 1 | 0 | 4,326,710 | 0 | ||
| ELEVATION ONCOLOGY INC | COM | 28623U101 | 11,861,586 | 2,312,200 | SH | DFND | 1 | 0 | 2,312,200 | 0 | ||
| ENGENE HOLDINGS INC | COM | 29286M105 | 38,155,077 | 2,251,037 | SH | DFND | 1 | 0 | 2,251,037 | 0 | ||
| ENGENE HOLDINGS INC | *W EXP 10/31/202 | 29286M113 | 4,916,090 | 945,402 | SH | DFND | 1 | 0 | 945,402 | 0 | ||
| ESSA PHARMA INC | COM NEW | 29668H708 | 74,275,860 | 8,748,629 | SH | DFND | 1 | 0 | 8,748,629 | 0 | ||
| FORTE BIOSCIENCES INC | COM | 34962G109 | 2,089,561 | 2,982,105 | SH | DFND | 1 | 0 | 2,982,105 | 0 | ||
| GALAPAGOS NV | SPON ADR | 36315X101 | 60,014,650 | 1,863,809 | SH | DFND | 1 | 0 | 1,863,809 | 0 | ||
| GH RESEARCH PLC | ORDINARY SHARES | G3855L106 | 110,865,684 | 10,400,158 | SH | DFND | 1 | 0 | 10,400,158 | 0 | ||
| GLYCOMIMETICS INC | COM | 38000Q102 | 28,632,786 | 9,544,262 | SH | DFND | 1 | 0 | 9,544,262 | 0 | ||
| IDEAYA BIOSCIENCES INC | COM | 45166A102 | 51,001,987 | 1,162,306 | SH | DFND | 1 | 0 | 1,162,306 | 0 | ||
| IKENA ONCOLOGY INC | COM | 45175G108 | 6,772,213 | 4,769,164 | SH | DFND | 1 | 0 | 4,769,164 | 0 | ||
| IMMUNIC INC | COM | 4525EP101 | 11,751,923 | 8,902,972 | SH | DFND | 1 | 0 | 8,902,972 | 0 | ||
| INVENTIVA SA | ADS | 46124U107 | 2,483,465 | 686,040 | SH | DFND | 1 | 0 | 686,040 | 0 | ||
| IONIS PHARMACEUTICALS INC | COM | 462222100 | 105,280,374 | 2,428,613 | SH | DFND | 1 | 0 | 2,428,613 | 0 | ||
| JANUX THERAPEUTICS INC | COM | 47103J105 | 109,931,148 | 2,919,818 | SH | DFND | 1 | 0 | 2,919,818 | 0 | ||
| KRONOS BIO INC | COM | 50107A104 | 3,776,556 | 2,905,043 | SH | DFND | 1 | 0 | 2,905,043 | 0 | ||
| KURA ONCOLOGY INC | COM | 50127T109 | 102,091,630 | 4,786,293 | SH | DFND | 1 | 0 | 4,786,293 | 0 | ||
| KYMERA THERAPEUTICS INC | COM | 501575104 | 207,504,400 | 5,161,801 | SH | DFND | 1 | 0 | 5,161,801 | 0 | ||
| LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 4,048,618 | 1,686,924 | SH | DFND | 1 | 0 | 1,686,924 | 0 | ||
| MERUS N V | COM | N5749R100 | 52,786,372 | 1,172,249 | SH | DFND | 1 | 0 | 1,172,249 | 0 | ||
| MIRUM PHARMACEUTICALS INC | COM | 604749101 | 109,775,003 | 4,370,024 | SH | DFND | 1 | 0 | 4,370,024 | 0 | ||
| MOLECULAR PARTNERS AG | ADS | 60853G106 | 1,719,697 | 443,221 | SH | DFND | 1 | 0 | 443,221 | 0 | ||
| MOLECULAR TEMPLATES INC | COM NEW | 608550208 | 1,169,813 | 522,238 | SH | DFND | 1 | 0 | 522,238 | 0 | ||
| MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 | 1,092,566,995 | 21,751,284 | SH | DFND | 1 | 0 | 21,751,284 | 0 | ||
| NEWAMSTERDAM PHARMA COMPANY | ORDINARY SHARES | N62509109 | 35,994,070 | 1,521,948 | SH | DFND | 1 | 0 | 1,521,948 | 0 | ||
| NLS PHARMACEUTICS LTD | SHS | H57830103 | 1,044,828 | 5,747,126 | SH | DFND | 1 | 0 | 5,747,126 | 0 | ||
| OLEMA PHARMACEUTICALS INC | COM | 68062P106 | 103,418,309 | 9,135,893 | SH | DFND | 1 | 0 | 9,135,893 | 0 | ||
| OVID THERAPEUTICS INC | COM | 690469101 | 11,754,145 | 3,853,818 | SH | DFND | 1 | 0 | 3,853,818 | 0 | ||
| PIERIS PHARMACEUTICALS INC | COM | 720795103 | 3,775,727 | 20,609,863 | SH | DFND | 1 | 0 | 20,609,863 | 0 | ||
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 108,660,791 | 3,755,990 | SH | DFND | 1 | 0 | 3,755,990 | 0 | ||
| REPARE THERAPEUTICS INC | COM | 760273102 | 48,671,256 | 10,333,600 | SH | DFND | 1 | 0 | 10,333,600 | 0 | ||
| REVOLUTION MEDICINES INC | COM | 76155X100 | 192,774,463 | 5,981,212 | SH | DFND | 1 | 0 | 5,981,212 | 0 | ||
| REZOLUTE INC | COM NEW | 76200L309 | 486,578 | 190,815 | SH | DFND | 1 | 0 | 190,815 | 0 | ||
| ROIVANT SCIENCES LTD | SHS | G76279101 | 28,904,991 | 2,742,409 | SH | DFND | 1 | 0 | 2,742,409 | 0 | ||
| SAB BIOTHERAPEUTICS INC | COM NEW | 78397T202 | 4,166,930 | 917,826 | SH | DFND | 1 | 0 | 917,826 | 0 | ||
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 | 34,844,666 | 812,988 | SH | DFND | 1 | 0 | 812,988 | 0 | ||
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 44,625,000 | 1,875,000 | SH | DFND | 1 | 0 | 1,875,000 | 0 | ||
| THIRD HARMONIC BIO INC | COM | 88427A107 | 41,214,408 | 4,365,933 | SH | DFND | 1 | 0 | 4,365,933 | 0 | ||
| TSCAN THERAPEUTICS INC | COM | 89854M101 | 23,736,424 | 2,989,474 | SH | DFND | 1 | 0 | 2,989,474 | 0 | ||
| TYRA BIOSCIENCES INC | COM | 90240B106 | 76,443,582 | 4,661,194 | SH | DFND | 1 | 0 | 4,661,194 | 0 | ||
| UNICYCIVE THERAPEUTICS INC | COM | 90466Y103 | 4,984,009 | 3,611,601 | SH | DFND | 1 | 0 | 3,611,601 | 0 | ||
| VERASTEM INC | COM NEW | 92337C203 | 19,885,584 | 1,685,219 | SH | DFND | 1 | 0 | 1,685,219 | 0 | ||
| VERVE THERAPEUTICS INC | COM | 92539P101 | 8,632,000 | 650,000 | SH | DFND | 1 | 0 | 650,000 | 0 | ||
| VIGIL NEUROSCIENCE INC | COM | 92673K108 | 6,184,489 | 1,813,633 | SH | DFND | 1 | 0 | 1,813,633 | 0 | ||
| VIRACTA THERAPEUTICS INC | COM | 92765F108 | 3,686,955 | 3,614,662 | SH | DFND | 1 | 0 | 3,614,662 | 0 | ||
| VISTAGEN THERAPEUTICS INC | COM | 92840H400 | 10,560,000 | 2,000,000 | SH | DFND | 1 | 0 | 2,000,000 | 0 | ||
| XOMA CORP DEL | COM NEW | 98419J206 | 87,391,519 | 3,633,743 | SH | DFND | 1 | 0 | 3,633,743 | 0 | ||
| ZYMEWORKS INC | COM | 98985Y108 | 61,752,400 | 5,870,000 | SH | DFND | 1 | 0 | 5,870,000 | 0 | ||