The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
4D MOLECULAR THERAPEUTICS IN COM 35104E100   81,190,187 4,007,413 SH   DFND 1 0 4,007,413 0
89BIO INC COM 282559103   45,208,944 4,047,354 SH   DFND 1 0 4,047,354 0
AC IMMUNE SA SHS H00263105   72,856,180 14,571,236 SH   DFND 1 0 14,571,236 0
ALLAKOS INC COM 01671P100   23,348,098 8,552,417 SH   DFND 1 0 8,552,417 0
AN2 THERAPEUTICS INC COM 037326105   32,045,602 1,563,963 SH   DFND 1 0 1,563,963 0
ANNEXON INC COM 03589W102   31,780,000 7,000,000 SH   DFND 1 0 7,000,000 0
ASLAN PHARMACEUTICALS LTD SPON ADS NEW 04522R200   548,204 1,049,999 SH   DFND 1 0 1,049,999 0
AXSOME THERAPEUTICS INC COM 05464T104   157,675,749 1,981,100 SH   DFND 1 0 1,981,100 0
CALLIDITAS THERAPEUTICS AB SPONSERED ADS 13124Q106   19,327,500 750,000 SH   DFND 1 0 750,000 0
CENTESSA PHARMACEUTICALS PLC SPONSORED ADS 152309100   69,845,577 8,774,570 SH   DFND 1 0 8,774,570 0
CIDARA THERAPEUTICS INC COM 171757107   5,447,735 6,861,127 SH   DFND 1 0 6,861,127 0
CORVUS PHARMACEUTICALS INC COM 221015100   2,412,867 1,370,947 SH   DFND 1 0 1,370,947 0
CULLINAN ONCOLOGY INC COM 230031106   32,574,383 3,196,701 SH   DFND 1 0 3,196,701 0
CYTOMX THERAPEUTICS INC COM 23284F105   10,223,492 6,595,801 SH   DFND 1 0 6,595,801 0
DELCATH SYS INC COM NEW 24661P807   4,060,780 976,149 SH   DFND 1 0 976,149 0
ELEDON PHARMACEUTICALS INC COM 28617K101   7,788,078 4,326,710 SH   DFND 1 0 4,326,710 0
ELEVATION ONCOLOGY INC COM 28623U101   1,241,651 2,312,200 SH   DFND 1 0 2,312,200 0
ENGENE HOLDINGS INC COM 29286M105   20,777,072 2,251,037 SH   DFND 1 0 2,251,037 0
ENGENE HOLDINGS INC *W EXP 10/31/202 29286M113   803,592 945,402 SH   DFND 1 0 945,402 0
ESSA PHARMA INC COM NEW 29668H708   57,740,951 8,748,629 SH   DFND 1 0 8,748,629 0
FORTE BIOSCIENCES INC COM 34962G109   2,450,396 2,982,105 SH   DFND 1 0 2,982,105 0
GALAPAGOS NV SPON ADR 36315X101   77,849,181 1,915,109 SH   DFND 1 0 1,915,109 0
GH RESEARCH PLC ORDINARY SHARES G3855L106   60,320,916 10,400,158 SH   DFND 1 0 10,400,158 0
GLYCOMIMETICS INC COM 38000Q102   22,524,458 9,544,262 SH   DFND 1 0 9,544,262 0
IDEAYA BIOSCIENCES INC COM 45166A102   61,519,350 1,729,043 SH   DFND 1 0 1,729,043 0
IKENA ONCOLOGY INC COM 45175G108   9,395,253 4,769,164 SH   DFND 1 0 4,769,164 0
IMMUNOVANT INC COM 45258J102   12,639,000 300,000 SH   DFND 1 0 300,000 0
INVENTIVA SA ADS 46124U107   3,073,459 686,040 SH   DFND 1 0 686,040 0
IONIS PHARMACEUTICALS INC COM 462222100   122,863,532 2,428,613 SH   DFND 1 0 2,428,613 0
ITEOS THERAPEUTICS INC COM 46565G104   13,791,262 1,259,476 SH   DFND 1 0 1,259,476 0
JANUX THERAPEUTICS INC COM 47103J105   49,141,447 4,579,818 SH   DFND 1 0 4,579,818 0
KRONOS BIO INC COM 50107A104   3,631,304 2,905,043 SH   DFND 1 0 2,905,043 0
KURA ONCOLOGY INC COM 50127T109   106,027,019 7,373,228 SH   DFND 1 0 7,373,228 0
KYMERA THERAPEUTICS INC COM 501575104   131,419,453 5,161,801 SH   DFND 1 0 5,161,801 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302   37,386,517 24,435,632 SH   DFND 1 0 24,435,632 0
MERUS N V COM N5749R100   75,691,550 2,752,420 SH   DFND 1 0 2,752,420 0
MIRUM PHARMACEUTICALS INC COM 604749101   129,003,108 4,370,024 SH   DFND 1 0 4,370,024 0
MOLECULAR PARTNERS AG ADS 60853G106   1,764,020 443,221 SH   DFND 1 0 443,221 0
MOLECULAR TEMPLATES INC COM NEW 608550208   1,968,541 532,038 SH   DFND 1 0 532,038 0
MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD 61559X104   1,313,560,041 21,751,284 SH   DFND 1 0 21,751,284 0
NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES N62509109   17,000,159 1,521,948 SH   DFND 1 0 1,521,948 0
NLS PHARMACEUTICS LTD SHS H57830103   3,390,230 5,747,126 SH   DFND 1 0 5,747,126 0
OLEMA PHARMACEUTICALS INC COM 68062P106   128,176,579 9,135,893 SH   DFND 1 0 9,135,893 0
OVID THERAPEUTICS INC COM 690469101   22,060,384 6,851,051 SH   DFND 1 0 6,851,051 0
PIERIS PHARMACEUTICALS INC COM 720795103   3,750,995 20,609,863 SH   DFND 1 0 20,609,863 0
PROTAGONIST THERAPEUTICS INC COM 74366E102   131,729,365 5,744,848 SH   DFND 1 0 5,744,848 0
RAIN ONCOLOGY INC COM 75082Q105   4,232,075 3,526,729 SH   DFND 1 0 3,526,729 0
RELAY THERAPEUTICS INC COM 75943R102   43,710,195 3,970,045 SH   DFND 1 0 3,970,045 0
REPARE THERAPEUTICS INC COM 760273102   75,435,280 10,333,600 SH   DFND 1 0 10,333,600 0
REVOLUTION MEDICINES INC COM 76155X100   171,541,160 5,981,212 SH   DFND 1 0 5,981,212 0
REZOLUTE INC COM NEW 76200L309   189,384 190,815 SH   DFND 1 0 190,815 0
ROIVANT SCIENCES LTD SHS G76279101   30,797,253 2,742,409 SH   DFND 1 0 2,742,409 0
SAB BIOTHERAPEUTICS INC COM 78397T103   6,310,069 9,178,282 SH   DFND 1 0 9,178,282 0
SILENCE THERAPEUTICS PLC ADS 82686Q101   26,201,186 1,508,416 SH   DFND 1 0 1,508,416 0
SPYRE THERAPEUTICS INC COM NEW 00773J202   14,785,962 687,080 SH   DFND 1 0 687,080 0
STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106   33,137,391 812,988 SH   DFND 1 0 812,988 0
SUTRO BIOPHARMA INC COM 869367102   14,362,688 3,347,946 SH   DFND 1 0 3,347,946 0
SYNDAX PHARMACEUTICALS INC COM 87164F105   40,518,750 1,875,000 SH   DFND 1 0 1,875,000 0
THIRD HARMONIC BIO INC COM 88427A107   47,894,285 4,365,933 SH   DFND 1 0 4,365,933 0
TSCAN THERAPEUTICS INC COM 89854M101   17,428,633 2,989,474 SH   DFND 1 0 2,989,474 0
TYRA BIOSCIENCES INC COM 90240B106   37,943,391 2,739,595 SH   DFND 1 0 2,739,595 0
UNICYCIVE THERAPEUTICS INC COM 90466Y103   1,837,909 2,118,139 SH   DFND 1 0 2,118,139 0
VERASTEM INC COM NEW 92337C203   13,717,683 1,685,219 SH   DFND 1 0 1,685,219 0
VERVE THERAPEUTICS INC COM 92539P101   9,061,000 650,000 SH   DFND 1 0 650,000 0
VIGIL NEUROSCIENCE INC COM 92673K108   6,130,080 1,813,633 SH   DFND 1 0 1,813,633 0
VIRACTA THERAPEUTICS INC COM 92765F108   2,060,357 3,614,662 SH   DFND 1 0 3,614,662 0
VISTAGEN THERAPEUTICS INC COM 92840H400   10,280,000 2,000,000 SH   DFND 1 0 2,000,000 0
XENON PHARMACEUTICALS INC COM 98420N105   40,996,716 890,072 SH   DFND 1 0 890,072 0
XOMA CORP DEL COM NEW 98419J206   67,224,246 3,633,743 SH   DFND 1 0 3,633,743 0
ZYMEWORKS INC COM 98985Y108   60,989,300 5,870,000 SH   DFND 1 0 5,870,000 0