The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ADURO BIOTECH INC | COM | 00739L101 | 5,809 | 513,603 | SH | DFND | 1 | 0 | 513,603 | 0 | |
| ARQULE INC | COM | 04269E107 | 14,155 | 7,450,128 | SH | DFND | 1 | 0 | 7,450,128 | 0 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 29,409 | 8,260,897 | SH | DFND | 1 | 0 | 8,260,897 | 0 | |
| AVIRAGEN THERAPEUTICS INC | COM | 053761102 | 292 | 208,353 | SH | DFND | 1 | 0 | 208,353 | 0 | |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 58,629 | 2,895,251 | SH | DFND | 1 | 0 | 2,895,251 | 0 | |
| CALITHERA BIOSCIENCES INC | COM | 13089P101 | 450 | 121,400 | SH | DFND | 1 | 0 | 121,400 | 0 | |
| CASCADIAN THERAPEUTICS INC | COM | 14740B101 | 17,730 | 18,799,368 | SH | DFND | 1 | 0 | 18,799,368 | 0 | |
| CATALYST BIOSCIENCES INC | COM | 14888D109 | 1,476 | 970,948 | SH | DFND | 1 | 0 | 970,948 | 0 | |
| CHEMOCENTRYX INC | COM | 16383L106 | 36,737 | 8,182,052 | SH | DFND | 1 | 0 | 8,182,052 | 0 | |
| CONCERT PHARMACEUTICALS INC | COM | 206022105 | 30,942 | 2,755,318 | SH | DFND | 1 | 0 | 2,755,318 | 0 | |
| CTI BIOPHARMA CORP | COM | 12648L106 | 15,231 | 44,796,940 | SH | DFND | 1 | 0 | 44,796,940 | 0 | |
| CYTOKINETICS INC | COM NEW | 23282W605 | 47,348 | 4,989,218 | SH | DFND | 1 | 0 | 4,989,218 | 0 | |
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 6,192 | 606,138 | SH | DFND | 1 | 0 | 606,138 | 0 | |
| ESPERION THERAPEUTICS INC NE | COM | 29664W105 | 4,932 | 499,142 | SH | DFND | 1 | 0 | 499,142 | 0 | |
| EXELIXIS INC | NOTE 4.250% 8/1 | 30161QAC8 | 33,935 | 22,822,778 | PRN | DFND | 1 | 0 | 22,822,778 | 0 | |
| FORWARD PHARMA A/S | SPONSORED ADR | 34986J105 | 25,885 | 1,424,611 | SH | DFND | 1 | 0 | 1,424,611 | 0 | |
| GLOBEIMMUNE INC | COM | 37957B100 | 1,276 | 657,653 | SH | DFND | 1 | 0 | 657,653 | 0 | |
| GLYCOMIMETICS INC | COM | 38000Q102 | 17,793 | 2,447,415 | SH | DFND | 1 | 0 | 2,447,415 | 0 | |
| GTX INC DEL | COM | 40052B108 | 6,332 | 11,512,000 | SH | DFND | 1 | 0 | 11,512,000 | 0 | |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 6,896 | 5,184,600 | SH | DFND | 1 | 0 | 5,184,600 | 0 | |
| IONIS PHARMACEUTICALS INC | COM | 462222100 | 19,797 | 850,000 | SH | DFND | 1 | 0 | 850,000 | 0 | |
| MACROGENICS INC | COM | 556099109 | 5,398 | 200,000 | SH | DFND | 1 | 0 | 200,000 | 0 | |
| MAST THERAPEUTICS INC | COM | 576314108 | 1,738 | 3,696,961 | SH | DFND | 1 | 0 | 3,696,961 | 0 | |
| NIVALIS THERAPEUTICS INC | COM | 65481J109 | 8,862 | 1,926,443 | SH | DFND | 1 | 0 | 1,926,443 | 0 | |
| ONCOMED PHARMACEUTICALS INC | COM | 68234X102 | 16,487 | 1,339,336 | SH | DFND | 1 | 0 | 1,339,336 | 0 | |
| OREXIGEN THERAPEUTICS INC | COM | 686164104 | 2,258 | 5,252,100 | SH | DFND | 1 | 0 | 5,252,100 | 0 | |
| PAIN THERAPEUTICS INC | COM | 69562K100 | 4,708 | 2,149,913 | SH | DFND | 1 | 0 | 2,149,913 | 0 | |
| PARATEK PHARMACEUTICALS INC | COM | 699374302 | 7,998 | 575,000 | SH | DFND | 1 | 0 | 575,000 | 0 | |
| PIERIS PHARMACEUTICALS INC | COM | 720795103 | 389 | 241,352 | SH | DFND | 1 | 0 | 241,352 | 0 | |
| QLT INC | COM | 746927102 | 3,203 | 2,255,476 | SH | DFND | 1 | 0 | 2,255,476 | 0 | |
| SUNESIS PHARMACEUTICALS INC | COM NEW | 867328601 | 2,636 | 4,813,294 | SH | DFND | 1 | 0 | 4,813,294 | 0 | |
| TOBIRA THERAPEUTICS INC | COM | 88883P101 | 15,743 | 1,253,401 | SH | DFND | 1 | 0 | 1,253,401 | 0 | |
| VITAE PHARMACEUTICALS INC | COM | 92847N103 | 8,212 | 761,079 | SH | DFND | 1 | 0 | 761,079 | 0 | |
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 10,511 | 1,775,572 | SH | DFND | 1 | 0 | 1,775,572 | 0 | |