SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person* ARTAL INTERNATIONAL SCA (Last) (First) (Middle) 10-12 AVENUE PASTEUR (Street) LUXEMBOURG N4 L-2310 (City) (State) (Zip)	2. Date of Event Requiring Statement (Month/Day/Year) 03/31/2012	3. Issuer Name and Ticker or Trading Symbol LEXICON PHARMACEUTICALS, INC./DE [ LXRX ]
		4. Relationship of Reporting Person(s) to Issuer (Check all applicable) X Director X 10% Owner Officer (give title below) Other (specify below)	5. If Amendment, Date of Original Filed (Month/Day/Year)
			6. Individual or Joint/Group Filing (Check Applicable Line) Form filed by One Reporting Person X Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock	250,372,135	I	See Footnotes(1)(2)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

1. Name and Address of Reporting Person* ARTAL INTERNATIONAL SCA (Last) (First) (Middle) 10-12 AVENUE PASTEUR (Street) LUXEMBOURG N4 L-2310 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer X Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* Artal International Management S.A. (Last) (First) (Middle) 10-12 AVENUE PASTEUR (Street) LUXEMBOURG N4 L-2310 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer X Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* ARTAL GROUP S A (Last) (First) (Middle) 10-12 AVENUE PASTEUR (Street) LUXEMBOURG N4 L-2310 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer X Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* WESTEND SA (Last) (First) (Middle) 10-12 AVENUE PASTEUR (Street) LUXEMBOURG N4 L-2310 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer X Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* Stichting Administratiekantoor Westend (Last) (First) (Middle) DE BOELELAAN 7, (Street) AMSTERDAM P7 NL-1083 HJ (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer X Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* Minne Pascal (Last) (First) (Middle) PLACE STE. GUDULE, 19 (Street) BRUXELLES C9 B-1000 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer X Director X 10% Owner Officer (give title below) Other (specify below)

Explanation of Responses:

1. 244,818,843 of the reported shares of Issuer common stock are owned directly by Invus, L.P. and 5,553,292 of the reported shares of Issuer common stock are owned directly by Invus Public Equities, L.P. Invus Advisors, L.L.C. is the general partner of Invus, L.P., and Invus Public Equities Advisors, LLC is the general partner of Invus Public Equities, L.P. Artal International S.C.A. is the managing member of each of Invus Advisors, L.L.C. and Invus Public Equities Advisors, LLC. Artal International Management S.A. is the general partner of Artal International S.C.A., which is a wholly owned subsidiary of Artal Group S.A., which is a wholly owned subsidiary of Westend S.A., which is a wholly owned subsidiary of Stichting Administratiekantoor Westend (the "Stichting"). (Continued in Footnote 2)

2. Mr. Pascal Minne is the sole member of the board of the Stichting. Accordingly, each of Artal International S.C.A., Artal International Management S.A., Artal Group S.A., Westend S.A., the Stichting and Mr. Minne may be deemed to be indirect beneficial owners of the reported securities. Each of Artal International S.C.A., Artal International Management S.A., Artal Group S.A., Westend S.A., the Stichting and Mr. Minne disclaims beneficial ownership of such securities, except to the extent of its or his pecuniary interest therein.

Remarks:

For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, Artal International S.C.A., Artal International Management S.A., Artal Group S.A., Westend S.A., the Stichting and Mr. Minne may be deemed to be directors by deputization of the Issuer by virtue of Invus, L.P.'s right to designate certain members of the Issuer's board of directors pursuant to a stockholders' agreement between the Issuer and Invus, L.P.

	/s/ Anne Goffard, Managing Director for ARTAL INTERNATIONAL MANAGEMENT S.A., managing partner for ARTAL INTERNATIONAL S.C.A.	04/10/2012
	/s/ Anne Goffard, Managing Director for ARTAL INTERNATIONAL MANAGEMENT S.A.	04/10/2012
	/s/ Anne Goffard, Authorized Person for ARTAL GROUP S.A.	04/10/2012
	/s/ Pascal Minne, Director for WESTEND S.A.	04/10/2012
	/s/ Pascal Minne, Sole Member of the Board for STICHTING ADMINISTRATIEKANTOOR WESTEND	04/10/2012
	/s/ Pascal Minne	04/10/2012
	** Signature of Reporting Person	Date
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