The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | |||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | ||||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | (to the nearest dollar) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| Acelyrin Inc | COM | 00445A100 | 16,234,715 | 2,405,143 | SH | DFND | 1,2,3,4,5 | 2,405,143 | 0 | 0 | ||
| Achilles Therapeutics PLC | SPONSORED ADS | 00449L102 | 944,219 | 755,375 | SH | DFND | 1,2,3,4,5 | 755,375 | 0 | 0 | ||
| Adagene Inc | ADS | 005329107 | 2,856,000 | 1,020,000 | SH | DFND | 1,2,3,4,5 | 1,020,000 | 0 | 0 | ||
| Adobe Inc | COM | 00724F101 | 1,564,260 | 3,100 | SH | DFND | 1,2,3,4,5 | 3,100 | 0 | 0 | ||
| Advanced Micro Devices Inc | COM | 007903107 | 812,205 | 4,500 | SH | DFND | 1,2,3,4,5 | 4,500 | 0 | 0 | ||
| Agenus Inc | COM NEW | 00847G705 | 9,066,116 | 15,631,235 | SH | DFND | 1,2,3,4,5 | 15,631,235 | 0 | 0 | ||
| Allovir Inc | COM | 019818103 | 4,980,201 | 6,597,167 | SH | DFND | 1,2,3,4,5 | 6,597,167 | 0 | 0 | ||
| Alphabet Inc | CAP STK CL A | 02079K305 | 1,056,510 | 7,000 | SH | DFND | 1,2,3,4,5 | 7,000 | 0 | 0 | ||
| Alpine Immune Sciences Inc | COM | 02083G100 | 16,085,278 | 405,784 | SH | DFND | 1,2,3,4,5 | 405,784 | 0 | 0 | ||
| Alto Neuroscience Inc | COM | 02157Q109 | 5,372,500 | 350,000 | SH | DFND | 1,2,3,4,5 | 350,000 | 0 | 0 | ||
| Amazon Com Inc | COM | 023135106 | 2,164,560 | 12,000 | SH | DFND | 1,2,3,4,5 | 12,000 | 0 | 0 | ||
| Amicus Therapeutics Inc | COM | 03152W109 | 11,918,721 | 1,011,776 | SH | DFND | 1,2,3,4,5 | 1,011,776 | 0 | 0 | ||
| Apellis Pharmaceuticals Inc | COM | 03753U106 | 77,312,276 | 1,315,282 | SH | DFND | 1,2,3,4,5 | 1,315,282 | 0 | 0 | ||
| Apogee Therapeutics Inc | COM | 03770N101 | 10,133,625 | 152,500 | SH | DFND | 1,2,3,4,5 | 152,500 | 0 | 0 | ||
| Apple Inc | COM | 037833100 | 1,714,800 | 10,000 | SH | DFND | 1,2,3,4,5 | 10,000 | 0 | 0 | ||
| Applied Therapeutics Inc | COM | 03828A101 | 6,864,600 | 1,009,500 | SH | DFND | 1,2,3,4,5 | 1,009,500 | 0 | 0 | ||
| Arrowhead Pharmaceuticals Inc | COM | 04280A100 | 17,160,000 | 600,000 | SH | Call | DFND | 1,2,3,4,5 | 600,000 | 0 | 0 | |
| Arrowhead Pharmaceuticals Inc | COM | 04280A100 | 86,848,705 | 3,036,668 | SH | DFND | 1,2,3,4,5 | 3,036,668 | 0 | 0 | ||
| Astria Therapeutics Inc | COM | 04635X102 | 12,445,312 | 884,214 | SH | DFND | 1,2,3,4,5 | 884,214 | 0 | 0 | ||
| Axsome Therapeutics Inc | COM | 05464T104 | 6,131,593 | 76,837 | SH | DFND | 1,2,3,4,5 | 76,837 | 0 | 0 | ||
| Beigene Ltd | SPONSORED ADR | 07725L102 | 63,303,857 | 404,782 | SH | DFND | 1,2,3,4,5 | 404,782 | 0 | 0 | ||
| Black Diamond Therapeutics Inc | COM | 09203E105 | 5,305,841 | 1,046,517 | SH | DFND | 1,2,3,4,5 | 1,046,517 | 0 | 0 | ||
| Caribou Biosciences Inc | COM | 142038108 | 541,484 | 105,347 | SH | DFND | 1,2,3,4,5 | 105,347 | 0 | 0 | ||
| Cartesian Therapeutics Inc | COM | 816212104 | 5,938,813 | 9,136,635 | SH | DFND | 1,2,3,4,5 | 9,136,635 | 0 | 0 | ||
| CAVA GROUP INC | COM | 148929102 | 1,856,884,700 | 26,507,990 | SH | DFND | 1,2,3,4 | 26,507,990 | 0 | 0 | ||
| Celldex Therapeutics Inc New | COM NEW | 15117B202 | 10,618,410 | 253,000 | SH | DFND | 1,2,3,4,5 | 253,000 | 0 | 0 | ||
| Centessa Pharmaceuticals PLC | SPONSORED ADS | 152309100 | 15,961,250 | 1,412,500 | SH | DFND | 1,2,3,4,5 | 1,412,500 | 0 | 0 | ||
| Clearwater Analytics Hldgs I | CL A | 185123106 | 442,250 | 25,000 | SH | DFND | 1,2,3,4,5 | 25,000 | 0 | 0 | ||
| Confluent Inc | CLASS A COM | 20717M103 | 579,880 | 19,000 | SH | DFND | 1,2,3,4,5 | 19,000 | 0 | 0 | ||
| Crinetics Pharmaceuticals Inc | COM | 22663K107 | 65,088,228 | 1,390,477 | SH | DFND | 1,2,3,4,5 | 1,390,477 | 0 | 0 | ||
| Cyclerion Therapeutics Inc | COM | 23255M204 | 442,890 | 138,403 | SH | DFND | 1,2,3,4,5 | 138,403 | 0 | 0 | ||
| Cyclerion Therapeutics Inc | COM | 23255M204 | 1,766 | 552 | SH | DFND | 1,2,3,4 | 552 | 0 | 0 | ||
| Cytokinetics Inc | COM NEW | 23282W605 | 35,516,604 | 506,584 | SH | DFND | 1,2,3,4,5 | 506,584 | 0 | 0 | ||
| Datadog Inc | CL A COM | 23804L103 | 1,186,560 | 9,600 | SH | DFND | 1,2,3,4,5 | 9,600 | 0 | 0 | ||
| Denali Therapeutics Inc | COM | 24823R105 | 10,319,487 | 502,899 | SH | DFND | 1,2,3,4,5 | 502,899 | 0 | 0 | ||
| Dlocal Ltd | CLASS A COM | G29018101 | 441,000 | 30,000 | SH | DFND | 1,2,3,4,5 | 30,000 | 0 | 0 | ||
| Dynatrace Inc | COM NEW | 268150109 | 1,671,840 | 36,000 | SH | DFND | 1,2,3,4,5 | 36,000 | 0 | 0 | ||
| Dyne Therapeutics Inc | COM | 26818M108 | 43,094,884 | 1,517,960 | SH | DFND | 1,2,3,4,5 | 1,517,960 | 0 | 0 | ||
| Edgewise Therapeutics Inc | COM | 28036F105 | 14,805,736 | 811,718 | SH | DFND | 1,2,3,4,5 | 811,718 | 0 | 0 | ||
| Elevation Oncology Inc | COM | 28623U101 | 7,761,767 | 1,513,015 | SH | DFND | 1,2,3,4,5 | 1,513,015 | 0 | 0 | ||
| Erasca Inc | COM | 29479A108 | 9,725,660 | 4,721,194 | SH | DFND | 1,2,3,4,5 | 4,721,194 | 0 | 0 | ||
| Fate Therapeutics Inc | COM | 31189P102 | 2,644,683 | 360,311 | SH | DFND | 1,2,3,4,5 | 360,311 | 0 | 0 | ||
| Foghorn Therapeutics Inc. | COM | 344174107 | 4,836,031 | 720,720 | SH | DFND | 1,2,3,4,5 | 720,720 | 0 | 0 | ||
| Generation Bio Co | COM | 37148K100 | 11,520,505 | 2,830,591 | SH | DFND | 1,2,3,4,5 | 2,830,591 | 0 | 0 | ||
| Geron Corp | COM | 374163103 | 4,227,940 | 1,281,194 | SH | DFND | 1,2,3,4,5 | 1,281,194 | 0 | 0 | ||
| GlycoMimetics Inc | COM | 38000Q102 | 25,767,192 | 8,589,064 | SH | DFND | 1,2,3,4,5 | 8,589,064 | 0 | 0 | ||
| Gossamer Bio Inc | COM | 38341P102 | 244,260 | 207,000 | SH | Call | DFND | 1,2,3,4,5 | 207,000 | 0 | 0 | |
| Gossamer Bio Inc | COM | 38341P102 | 15,704,582 | 13,308,968 | SH | DFND | 1,2,3,4,5 | 13,308,968 | 0 | 0 | ||
| Gritstone Bio Inc | COM | 39868T105 | 2,649,547 | 1,030,952 | SH | DFND | 1,2,3,4,5 | 1,030,952 | 0 | 0 | ||
| Hippo Hldgs Inc | COM NEW | 433539202 | 438,480 | 24,000 | SH | DFND | 1,2,3,4,5 | 24,000 | 0 | 0 | ||
| HOOKIPA Pharma Inc | COM | 43906K100 | 4,034,484 | 5,666,410 | SH | DFND | 1,2,3,4,5 | 5,666,410 | 0 | 0 | ||
| IGM Biosciences Inc | COM | 449585108 | 29,726,072 | 3,080,422 | SH | DFND | 1,2,3,4,5 | 3,080,422 | 0 | 0 | ||
| Intapp Inc | COM | 45827U109 | 1,011,850 | 29,500 | SH | DFND | 1,2,3,4,5 | 29,500 | 0 | 0 | ||
| Ironwood Pharmaceuticals Inc | COM CL A | 46333X108 | 962,734 | 110,532 | SH | DFND | 1,2,3,4 | 110,532 | 0 | 0 | ||
| Janux Therapeutics Inc | COM | 47103J105 | 1,882,500 | 50,000 | SH | DFND | 1,2,3,4,5 | 50,000 | 0 | 0 | ||
| Ke Holdings Inc | SPONSORED ADS | 482497104 | 3,775,750 | 275,000 | SH | DFND | 1,2,3,4,5 | 275,000 | 0 | 0 | ||
| Korro Bio Inc | COM | 500946108 | 37,730,340 | 419,226 | SH | DFND | 1,2,3,4,5 | 419,226 | 0 | 0 | ||
| Kronos Bio Inc | COM | 50107A104 | 1,095,840 | 842,954 | SH | DFND | 1,2,3,4,5 | 842,954 | 0 | 0 | ||
| Kura Oncology Inc | COM | 50127T109 | 40,951,126 | 1,919,884 | SH | DFND | 1,2,3,4,5 | 1,919,884 | 0 | 0 | ||
| Kymera Therapeutics Inc | COM | 501575104 | 121,690,827 | 3,027,135 | SH | DFND | 1,2,3,4,5 | 3,027,135 | 0 | 0 | ||
| Kyverna Therapeutics Inc | COM | 501976104 | 4,968,000 | 200,000 | SH | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 | ||
| Lexeo Therapeutics Inc | COM | 52886X107 | 12,570,907 | 801,716 | SH | DFND | 1,2,3,4,5 | 801,716 | 0 | 0 | ||
| Lexicon Pharmaceuticals Inc | COM NEW | 528872302 | 8,438,914 | 3,516,214 | SH | DFND | 1,2,3,4,5 | 3,516,214 | 0 | 0 | ||
| Lexicon Pharmaceuticals Inc | COM NEW | 528872302 | 273,688,968 | 114,037,070 | SH | DFND | 1,2,3,4 | 114,037,070 | 0 | 0 | ||
| Madrigal Pharmaceuticals Inc | COM | 558868105 | 29,509,789 | 110,507 | SH | DFND | 1,2,3,4,5 | 110,507 | 0 | 0 | ||
| Merus N V | COM | N5749R100 | 20,492,297 | 455,081 | SH | DFND | 1,2,3,4,5 | 455,081 | 0 | 0 | ||
| Metagenomi Inc | COM | 59102M104 | 3,165,000 | 300,000 | SH | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 | ||
| Microsoft Corp | COM | 594918104 | 1,051,800 | 2,500 | SH | DFND | 1,2,3,4,5 | 2,500 | 0 | 0 | ||
| Mink Therapeutics Inc | COM | 603693102 | 1,740 | 1,916 | SH | DFND | 1,2,3,4,5 | 1,916 | 0 | 0 | ||
| MongoDB Inc | CL A | 60937P106 | 717,280 | 2,000 | SH | DFND | 1,2,3,4,5 | 2,000 | 0 | 0 | ||
| Morphic Hldg Inc | COM | 61775R105 | 77,904,218 | 2,213,188 | SH | DFND | 1,2,3,4,5 | 2,213,188 | 0 | 0 | ||
| Neumora Therapeutics Inc | COM | 640979100 | 40,205,715 | 2,924,052 | SH | DFND | 1,2,3,4,5 | 2,924,052 | 0 | 0 | ||
| New Oriental Ed & Technology | SPONSORED ADR | 647581206 | 1,302,300 | 15,000 | SH | DFND | 1,2,3,4,5 | 15,000 | 0 | 0 | ||
| NewAmsterdam Pharma Company | ORDINARY SHARES | N62509109 | 18,920,000 | 800,000 | SH | DFND | 1,2,3,4,5 | 800,000 | 0 | 0 | ||
| NVIDIA Corporation | COM | 67066G104 | 1,716,764 | 1,900 | SH | DFND | 1,2,3,4,5 | 1,900 | 0 | 0 | ||
| Omega Therapeutics Inc | COM | 68217N105 | 4,830,885 | 1,323,530 | SH | DFND | 1,2,3,4,5 | 1,323,530 | 0 | 0 | ||
| Ovid Therapeutics Inc | COM | 690469101 | 7,625,000 | 2,500,000 | SH | DFND | 1,2,3,4,5 | 2,500,000 | 0 | 0 | ||
| Palo Alto Networks Inc | COM | 697435105 | 852,390 | 3,000 | SH | DFND | 1,2,3,4,5 | 3,000 | 0 | 0 | ||
| PayPal Hldgs Inc | COM | 70450Y103 | 3,885,420 | 58,000 | SH | Call | DFND | 1,2,3,4,5 | 58,000 | 0 | 0 | |
| PayPal Hldgs Inc | COM | 70450Y103 | 669,900 | 10,000 | SH | DFND | 1,2,3,4,5 | 10,000 | 0 | 0 | ||
| PDD Holdings Inc | SPONSORED ADS | 722304102 | 6,568,125 | 56,500 | SH | DFND | 1,2,3,4,5 | 56,500 | 0 | 0 | ||
| Pegasystems Inc | COM | 705573103 | 743,360 | 11,500 | SH | DFND | 1,2,3,4,5 | 11,500 | 0 | 0 | ||
| PepGen Inc | COM | 713317105 | 2,940,000 | 200,000 | SH | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 | ||
| Procore Technologies Inc | COM | 74275K108 | 780,615 | 9,500 | SH | DFND | 1,2,3,4,5 | 9,500 | 0 | 0 | ||
| Prothena Corp PLC | SHS | G72800108 | 24,803,687 | 1,001,360 | SH | DFND | 1,2,3,4,5 | 1,001,360 | 0 | 0 | ||
| Regenxbio Inc | COM | 75901B107 | 5,267,500 | 250,000 | SH | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 | ||
| Repare Therapeutics Inc | COM | 760273102 | 3,297,000 | 700,000 | SH | DFND | 1,2,3,4,5 | 700,000 | 0 | 0 | ||
| Revolution Medicines Inc | COM | 76155X100 | 42,500,057 | 1,318,649 | SH | DFND | 1,2,3,4,5 | 1,318,649 | 0 | 0 | ||
| Sagimet Biosciences Inc | COM SER A | 786700104 | 3,928,259 | 724,771 | SH | DFND | 1,2,3,4,5 | 724,771 | 0 | 0 | ||
| Scholar Rock Hldg Corp | COM | 80706P103 | 199,967,619 | 11,259,438 | SH | DFND | 1,2,3,4,5 | 11,259,438 | 0 | 0 | ||
| Sea Ltd | SPONSORED ADS | 81141R100 | 12,756,125 | 237,500 | SH | DFND | 1,2,3,4,5 | 237,500 | 0 | 0 | ||
| Seer Inc | COM CL A | 81578P106 | 9,025,000 | 4,750,000 | SH | DFND | 1,2,3,4,5 | 4,750,000 | 0 | 0 | ||
| Silence Therapeutics PLC | ADS | 82686Q101 | 60,039,770 | 2,779,619 | SH | DFND | 1,2,3,4,5 | 2,779,619 | 0 | 0 | ||
| Snowflake Inc | CL A | 833445109 | 1,050,400 | 6,500 | SH | DFND | 1,2,3,4,5 | 6,500 | 0 | 0 | ||
| Solid Biosciences Inc | COM NEW | 83422E204 | 33,300,000 | 2,500,000 | SH | DFND | 1,2,3,4,5 | 2,500,000 | 0 | 0 | ||
| Spdr Ser Tr | S&P BIOTECH | 78464A870 | 23,722,500 | 250,000 | SH | Call | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 | |
| SpringWorks Therapeutics Inc | COM | 85205L107 | 69,663,429 | 1,415,348 | SH | DFND | 1,2,3,4,5 | 1,415,348 | 0 | 0 | ||
| Stoke Therapeutics Inc | COM | 86150R107 | 4,050,000 | 300,000 | SH | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 | ||
| Structure Therapeutics Inc | SPONSORED ADS | 86366E106 | 6,505,291 | 151,780 | SH | DFND | 1,2,3,4,5 | 151,780 | 0 | 0 | ||
| Syros Pharmaceuticals Inc | COM NEW | 87184Q206 | 13,401,820 | 2,505,013 | SH | DFND | 1,2,3,4,5 | 2,505,013 | 0 | 0 | ||
| Taiwan Semiconductor Mfg Ltd | SPONSORED ADS | 874039100 | 4,353,600 | 32,000 | SH | DFND | 1,2,3,4,5 | 32,000 | 0 | 0 | ||
| Tango Therapeutics Inc | COM | 87583X109 | 17,427,038 | 2,194,841 | SH | DFND | 1,2,3,4,5 | 2,194,841 | 0 | 0 | ||
| Taysha Gene Therapies Inc | COM SHS | 877619106 | 10,583,263 | 3,687,548 | SH | DFND | 1,2,3,4,5 | 3,687,548 | 0 | 0 | ||
| Tesla Inc | COM | 88160R101 | 351,580 | 2,000 | SH | DFND | 1,2,3,4,5 | 2,000 | 0 | 0 | ||
| Tourmaline Bio Inc | COM | 89157D105 | 7,201,958 | 314,496 | SH | DFND | 1,2,3,4,5 | 314,496 | 0 | 0 | ||
| Ultragenyx Pharmaceutical Inc | COM | 90400D108 | 8,307,645 | 177,932 | SH | DFND | 1,2,3,4,5 | 177,932 | 0 | 0 | ||
| Vera Therapeutics Inc | CL A | 92337R101 | 21,819,539 | 506,019 | SH | DFND | 1,2,3,4,5 | 506,019 | 0 | 0 | ||
| Vigil Neuroscience Inc | COM | 92673K108 | 6,176,161 | 1,811,191 | SH | DFND | 1,2,3,4,5 | 1,811,191 | 0 | 0 | ||
| Viking Therapeutics Inc | COM | 92686J106 | 20,816,766 | 253,863 | SH | DFND | 1,2,3,4,5 | 253,863 | 0 | 0 | ||
| Visa Inc | COM CL A | 92826C839 | 697,700 | 2,500 | SH | DFND | 1,2,3,4,5 | 2,500 | 0 | 0 | ||
| Vor Biopharma Inc | COM | 929033108 | 2,370,000 | 1,000,000 | SH | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 | ||
| WAVE Life Sciences Ltd | SHS | Y95308105 | 24,997,138 | 4,051,400 | SH | DFND | 1,2,3,4,5 | 4,051,400 | 0 | 0 | ||
| Xenon Pharmaceuticals Inc | COM | 98420N105 | 10,908,310 | 253,387 | SH | DFND | 1,2,3,4,5 | 253,387 | 0 | 0 | ||