The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
23ANDME HOLDING CO CLASS A COM 90138Q108   646 661,009 SH   DFND 1,2,3,4,5 661,009 0 0
ACELYRIN INC COM 00445A100   25,113 2,469,279 SH   DFND 1,2,3,4,5 2,469,279 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102   2,052 2,255,375 SH   DFND 1,2,3,4,5 2,255,375 0 0
ADAGENE INC ADS 005329107   1,530 1,000,000 SH   DFND 1,2,3,4,5 1,000,000 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONSORED ADR 00653A107   884 1,133,775 SH   DFND 1,2,3,4,5 1,133,775 0 0
ADVANCED MICRO DEVICES INC COM 007903107   617 6,000 SH   DFND 1,2,3,4,5 6,000 0 0
AGENUS INC COM NEW 00847G705   17,663 15,631,235 SH   DFND 1,2,3,4,5 15,631,235 0 0
ALLOVIR INC COM 019818103   14,184 6,597,167 SH   DFND 1,2,3,4,5 6,597,167 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107   166 936 SH   DFND 1,2,3,4,5 936 0 0
ALPHABET INC CAP STK CL A 02079K305   720 5,500 SH   DFND 1,2,3,4,5 5,500 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100   13,660 1,193,030 SH   DFND 1,2,3,4,5 1,193,030 0 0
AMAZON COM INC COM 023135106   1,525 12,000 SH   DFND 1,2,3,4,5 12,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109   49,401 4,062,567 SH   DFND 1,2,3,4,5 4,062,567 0 0
AMICUS THERAPEUTICS INC COM 03152W109   6,080 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106   63,320 1,664,572 SH   DFND 1,2,3,4,5 1,664,572 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100   146 5,440 SH   DFND 1,2,3,4,5 5,440 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102   7,770 1,000,000 SH   DFND 1,2,3,4,5 1,000,000 0 0
AVIDITY BIOSCIENCES INC COM 05370A108   1,914 300,000 SH   DFND 1,2,3,4,5 300,000 0 0
BEAM THERAPEUTICS INC COM 07373V105   264 10,975 SH   DFND 1,2,3,4,5 10,975 0 0
BEIGENE LTD SPONSORED ADR 07725L102   72,656 403,934 SH   DFND 1,2,3,4,5 403,934 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105   5,874 2,046,517 SH   DFND 1,2,3,4,5 2,046,517 0 0
BLOCK INC CL A 852234103   686 15,500 SH   DFND 1,2,3,4,5 15,500 0 0
CARIBOU BIOSCIENCES INC COM 142038108   504 105,347 SH   DFND 1,2,3,4,5 105,347 0 0
CAVA GROUP INC COM 148929102   980,405 32,007,990 SH   DFND 1,2,3,4 32,007,990 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128   35,776 1,638,858 SH   DFND 1,2,3,4,5 1,638,858 0 0
CROWDSTRIKE HLDGS INC CL A 22788C105   335 2,000 SH   DFND 1,2,3,4,5 2,000 0 0
CURIS INC COM 231269309   692 105,000 SH   DFND 1,2,3,4,5 105,000 0 0
CYCLERION THERAPEUTICS INC COM 23255M204   473 138,403 SH   DFND 1,2,3,4,5 138,403 0 0
CYCLERION THERAPEUTICS INC COM 23255M105   2 552 SH   DFND 1,2,3,4 552 0 0
CYTOKINETICS INC COM NEW 23282W605   44,745 1,518,831 SH   DFND 1,2,3,4,5 1,518,831 0 0
DATADOG INC CL A COM 23804L103   1,048 11,500 SH   DFND 1,2,3,4,5 11,500 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109   6,135 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
DENALI THERAPEUTICS INC COM 24823R105   16,564 802,899 SH   DFND 1,2,3,4,5 802,899 0 0
DYNE THERAPEUTICS INC COM 26818M108   7,303 815,085 SH   DFND 1,2,3,4,5 815,085 0 0
ERASCA INC COM 29479A108   9,301 4,721,194 SH   DFND 1,2,3,4,5 4,721,194 0 0
FOGHORN THERAPEUTICS INC COM 344174107   8,604 1,720,720 SH   DFND 1,2,3,4,5 1,720,720 0 0
FUSION PHARMACEUTICALS INC COM 36118A100   4,485 1,725,000 SH   DFND 1,2,3,4,5 1,725,000 0 0
GENERATION BIO CO COM 37148K100   10,666 2,814,191 SH   DFND 1,2,3,4,5 2,814,191 0 0
GERON CORP COM 374163103   11,800 5,565,889 SH   DFND 1,2,3,4,5 5,565,889 0 0
GLYCOMIMETICS INC COM 38000Q102   12,884 8,589,064 SH   DFND 1,2,3,4,5 8,589,064 0 0
GOSSAMER BIO INC COM 38341P102   5,330 6,399,819 SH   DFND 1,2,3,4,5 6,399,819 0 0
HARPOON THERAPEUTICS INC COM NEW 41358P205   403 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
HIPPO HLDGS INC COM NEW 433539202   191 24,000 SH   DFND 1,2,3,4,5 24,000 0 0
HOOKIPA PHARMA INC COM 43906K100   3,491 5,666,410 SH   DFND 1,2,3,4,5 5,666,410 0 0
IGM BIOSCIENCES INC COM 449585108   21,061 2,522,244 SH   DFND 1,2,3,4,5 4,209,744 0 0
IKENA ONCOLOGY INC COM 45175G108   8,008 1,849,513 SH   DFND 1,2,3,4,5 1,849,513 0 0
I MAB SPONSORED ADS 44975P103   1,122 850,000 SH   DFND 1,2,3,4,5 850,000 0 0
IMMUNOGEN INC COM 45253H101   23,997 1,512,113 SH   DFND 1,2,3,4,5 1,512,113 0 0
INTAPP INC COM 45827U109   335 10,000 SH   DFND 1,2,3,4,5 10,000 0 0
INTELLIA THERAPEUTICS INC COM 45826J105   8,730 276,077 SH   DFND 1,2,3,4,5 276,077 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108   1,064 110,532 SH   DFND 1,2,3,4 110,532 0 0
ITEOS THERAPEUTICS INC COM 46565G104   4,380 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
KANZHUN LIMITED SPONSORED ADS 48553T106   3,337 220,000 SH   DFND 1,2,3,4,5 220,000 0 0
KE HLDGS INC SPONSORED ADS 482497104   4,268 275,000 SH   DFND 1,2,3,4,5 275,000 0 0
KINETA INC COM 49461C102   106 31,055 SH   DFND 1,2,3,4,5 31,055 0 0
KRONOS BIO INC COM 50107A104   2,006 1,542,954 SH   DFND 1,2,3,4,5 1,542,954 0 0
KURA ONCOLOGY INC COM 50127T109   18,405 2,018,056 SH   DFND 1,2,3,4,5 2,018,056 0 0
KYMERA THERAPEUTICS INC COM 501575104   25,094 1,805,346 SH   DFND 1,2,3,4,5 1,805,346 0 0
LAVA THERAPEUTICS NV SHS N51517105   294 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302   3,833 3,516,214 SH   DFND 1,2,3,4,5 3,516,214 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302   124,300 114,037,070 SH   DFND 1,2,3,4 114,037,070 0 0
MICROSOFT CORP COM 594918104   1,737 5,500 SH   DFND 1,2,3,4,5 5,500 0 0
MINK THERAPEUTICS INC COM 603693102   2 1,916 SH   DFND 1,2,3,4,5 1,916 0 0
MIRATI THERAPEUTICS INC COM 60468T105   88,175 2,024,226 SH   DFND 1,2,3,4,5 2,024,226 0 0
MIRATI THERAPEUTICS INC COM 60468T105   30,492 700,000 SH Call DFND 1,2,3,4,5 700,000 0 0
MORPHIC HLDG INC COM 61775R105   48,986 2,138,188 SH   DFND 1,2,3,4,5 2,138,188 0 0
NANOBIOTIX SPONSORED ADS 63009J107   8,750 1,000,000 SH   DFND 1,2,3,4,5 1,000,000 0 0
NATERA INC COM 632307104   8,850 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
NETFLIX INC COM 64110L106   485 1,285 SH   DFND 1,2,3,4,5 1,285 0 0
NEUMORA THERAPEUTICS INC COM 640979100   39,546 2,802,702 SH   DFND 1,2,3,4,5 2,802,702 0 0
OMEGA THERAPEUTICS INC COM 68217N105   5,446 2,533,045 SH   DFND 1,2,3,4,5 2,533,045 0 0
OVID THERAPEUTICS INC COM 690469101   9,600 2,500,000 SH   DFND 1,2,3,4,5 2,500,000 0 0
PAYPAL HLDGS INC COM 70450Y103   292 5,000 SH   DFND 1,2,3,4,5 5,000 0 0
PAYPAL HLDGS INC COM 70450Y103   1,871 32,000 SH Call DFND 1,2,3,4,5 32,000 0 0
PEGASYSTEMS INC COM 705573103   326 7,500 SH   DFND 1,2,3,4,5 7,500 0 0
PLIANT THERAPEUTICS INC COM 729139105   26 1,490 SH   DFND 1,2,3,4,5 1,490 0 0
PROCORE TECHNOLOGIES INC COM 74275K108   294 4,500 SH   DFND 1,2,3,4,5 4,500 0 0
RAYZEBIO INC COM 75525N107   12,333 555,556 SH   DFND 1,2,3,4,5 555,556 0 0
REPARE THERAPEUTICS INC COM 760273102   8,456 700,000 SH   DFND 1,2,3,4,5 700,000 0 0
REPLIMUNE GROUP INC COM 76029N106   8,555 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
REVOLUTION MEDICINES INC COM 76155X100   70,023 2,529,737 SH   DFND 1,2,3,4,5 2,529,737 0 0
ROIVANT SCIENCES LTD SHS G76279101   11,680 1,000,000 SH   DFND 1,2,3,4,5 1,000,000 0 0
SAGIMET BIOSCIENCES INC COM SER A 786700104   8,138 924,771 SH   DFND 1,2,3,4,5 924,771 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103   64,322 9,059,507 SH   DFND 1,2,3,4,5 9,059,507 0 0
SCHRODINGER INC COM 80810D103   14,135 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
SEA LTD SPONSORED ADS 81141R100   17,448 397,000 SH   DFND 1,2,3,4,5 397,000 0 0
SEER INC COM CL A 81578P106   10,498 4,750,000 SH   DFND 1,2,3,4,5 4,750,000 0 0
SELECTA BIOSCIENCES INC COM 816212104   9,685 9,136,635 SH   DFND 1,2,3,4,5 9,136,635 0 0
SENTI BIOSCIENCES INC COM 81726A100   23 55,555 SH   DFND 1,2,3,4,5 55,555 0 0
SILENCE THERAPEUTICS PLC ADS 82686Q101   24,550 2,500,000 SH   DFND 1,2,3,4,5 2,500,000 0 0
SOLID BIOSCIENCES INC COM NEW 83422E204   2,291 909,219 SH   DFND 1,2,3,4,5 909,219 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107   42,000 1,816,620 SH   DFND 1,2,3,4,5 1,816,620 0 0
SQZ BIOTECHNOLOGIES CO COM 78472W104   129 1,606,309 SH   DFND 1,2,3,4,5 1,606,309 0 0
SYROS PHARMACEUTICALS INC COM NEW 87184Q206   5,829 1,475,744 SH   DFND 1,2,3,4,5 1,475,744 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100   8,925 102,699 SH   DFND 1,2,3,4,5 102,699 0 0
TAYSHA GENE THERAPIES INC COM SHS 877619106   11,575 3,663,104 SH   DFND 1,2,3,4,5 3,663,104 0 0
TALARIS THERAPEUTICS INC COM 87410C104   2,569 914,262 SH   DFND 1,2,3,4,5 914,262 0 0
VENTYX BIOSCIENCES INC COM 92332V107   14,074 405,239 SH   DFND 1,2,3,4,5 405,239 0 0
VERVE THERAPEUTICS INC COM 92539P101   3,978 300,000 SH   DFND 1,2,3,4,5 300,000 0 0
VIGIL NEUROSCIENCE INC COM 92673K108   10,285 1,908,135 SH   DFND 1,2,3,4,5 1,908,135 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104   7,746 504,978 SH   DFND 1,2,3,4,5 504,978 0 0
VISA INC COM CL A 92826C839   1,725 7,500 SH   DFND 1,2,3,4,5 7,500 0 0
VOR BIOPHARMA INC COM 929033108   5,699 2,688,015 SH   DFND 1,2,3,4,5 2,688,015 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105   11,500 2,000,000 SH   DFND 1,2,3,4,5 2,000,000 0 0
XILIO THERAPEUTICS INC COM 98422T100   950 450,000 SH   DFND 1,2,3,4,5 450,000 0 0