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Note 10 - Stock-based Compensation (Tables)
3 Months Ended
Mar. 31, 2024
Notes Tables  
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
   

Three Months Ended

March 31,

 
   

2024

   

2023

 

Research and development

  $ 63,797     $ 40,126  

General and administrative

    154,418       31,114  

Total stock-based compensation expense

  $ 218,215     $ 71,240  
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
   

Number of

Options

   

Weighted

average

exercise price

per share

   

Weighted

average

remaining

contractual life

(in years)

   

Aggregate

intrinsic value

 

Balance at January 1, 2024

    349,374     $ 51.15                  

Granted

    169,934       9.52                  

Expired

    (51 )     28,897.06                  

Outstanding at March 31, 2024

    519,257     $ 34.69       8.5        

Exercisable at March 31, 2024

    192,004     $ 79.03       6.7        
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
   

Three Months Ended

March 31,

 
   

2024

 

Expected term (in years)

    5.74 - 5.76  

Risk-free interest rate

    4.06 - 4.14 %

Expected volatility

    79.13 - 79.31 %

Dividend yield