Note 12 - Stock-based Compensation (Tables)

9 Months Ended

Sep. 30, 2023

Notes Tables

Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]

	Three Months Ended September 30,				Nine Months Ended September 30,
	2023		2022		2023		2022
Research and development	$	30,737	$	41,546	$	101,885	$	134,559
General and administrative		78,431		40,838		140,775		118,288
Total stock-based compensation expense	$	109,168	$	82,384	$	242,660	$	252,847

Share-Based Payment Arrangement, Option, Activity [Table Text Block]

	Number of Options		Weighted average exercise price per share
Balance at January 1, 2023		114,516	$	25.98
Options assumed in the Merger		52,574	$	313.67
Granted		162,250	$	5.33
Outstanding at September 30, 2023		329,340	$	61.73
Exercisable at September 30, 2023		148,912	$	111.77

Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

	September 30,
	2023		2022
Expected term (in years)		5.75		6.00
Risk-free interest rate		4.4%		1.9%
Expected volatility		81.7%		80.3%
Dividend yield		0.0%		0.0%