Note 8- Stock-based Compensation (10 Q) (Tables)

3 Months Ended

12 Months Ended

Mar. 31, 2023

Dec. 31, 2022

Notes Tables

Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]

	Three Months Ended March 31,
	2023		2022
Research and development	$	12,011	$	58,892
General and administrative		109,360		219,239
Total stock-based compensation expense	$	121,371	$	278,131

	December 31,
	2022		2021
Research and development	$	215,904	$	154,041
General and administrative		712,148		743,219
Total stock-based compensation expense	$	928,052	$	897,260

Share-Based Payment Arrangement, Option, Activity [Table Text Block]

	Number of Options			Weighted average exercise price per share		Weighted average remaining contractual life (in years)		Aggregate intrinsic value
Balance at January 1, 2023		140,040		$	126.75
Granted		—			—
Cancelled		(35,993	)		20.13
Outstanding at March 31, 2023		104,047		$	163.64		7.99	$	—
Exercisable at March 31, 2023		78,533		$	211.21		7.75	$	—
Vested and expected to vest at March 31, 2023		104,047		$	163.64		7.99	$	—

	Number of Options			Weighted average exercise price per share		Weighted average remaining contractual term (in years)		Aggregate Intrinsic Value
Balance at January 1, 2021		44,738		$	407.60
Granted		36,310			44.66
Expired		(8,594	)		68.48
Balance at December 31, 2021		72,454			265.91
Granted		77,088			9.87
Forfeited		(8,892	)		147.28
Expired		(610	)		1,562.92
Outstanding at December 31, 2022		140,040			126.75		8.5		—
Exercisable at December 31, 2022		74,086		$	226.95		7.9		—
Vested and expected to vest at December 31, 2022		140,040		$	126.75		8.5		—

Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]

	Number of Units			Weighted average grant date fair value
Balance at January 1, 2023		3,652		$	36.49
Vested (1)		(742	)		33.72
Outstanding at March 31, 2023		2,910		$	38.28

	Number of Units			Weighted average grant date fair value
Balance at January 1, 2022		5,509		$	34.78
Vested(1)		(1,857	)		31.41
Outstanding at December 31, 2022		3,652			36.49