Consolidated Statements of Changes in Stockholders' Equity - USD ($)	Common Stock [Member]	Additional Paid-in Capital [Member]	Retained Earnings [Member]	Total
Balance (in shares) at Dec. 31, 2018	3,376,230
Balance at Dec. 31, 2018	$ 3,377	$ 95,532,881	$ (79,924,699)	$ 15,611,559
Issuance of common stock, pre-funded warrants and warrants, net of issuance costs (in shares)	12,688,276
Issuance of common stock, pre-funded warrants and warrants, net of issuance costs	$ 12,688	11,905,207		11,917,895
Issuance of common stock upon exercise of warrants (in shares)	17,415,859
Issuance of common stock upon exercise of warrants	$ 17,416	3,871,009		3,888,425
Stock-based compensation expense		515,762		515,762
Net loss			(11,799,379)	(11,799,379)
Balance (in shares) at Dec. 31, 2019	33,480,365
Balance at Dec. 31, 2019	$ 33,481	111,824,859	(91,724,078)	20,134,262
Issuance of common stock, pre-funded warrants and warrants, net of issuance costs (in shares)	11,428,572
Issuance of common stock, pre-funded warrants and warrants, net of issuance costs	$ 11,429	10,330,202		10,341,631
Issuance of common stock upon exercise of warrants (in shares)	19,106,504
Issuance of common stock upon exercise of warrants	$ 19,106	7,768,370		7,787,476
Stock-based compensation expense		736,119		736,119
Net loss			(14,185,306)	(14,185,306)
Balance (in shares) at Dec. 31, 2020	64,015,441
Balance at Dec. 31, 2020	$ 64,016	$ 130,659,550	$ (105,909,384)	$ 24,814,182