Note 9 - Income Taxes - Reconciliation of Income Tax Rate (Details)	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019
Federal tax benefit at statutory rate	(21.00%)	(21.00%)
State tax, net of Federal benefit	(4.70%)	(2.50%)
Orphan drug credit	(2.90%)	25.30%
Change in valuation allowance	18.10%	(7.50%)
Stock compensation		8.60%
Other		0.10%
Total provision	(10.50%)	3.00%