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Note 3 - Basis of Presentation and Summary of Significant Accounting Policies - Outstanding Dilutive Securities (Details) - shares
12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Anti-dilutive securities (in shares) 11,340,316 22,694,417
Warrant [Member]    
Anti-dilutive securities (in shares) 9,100,112 22,385,141
Share-based Payment Arrangement, Option [Member]    
Anti-dilutive securities (in shares) 2,240,204 309,276