Note 9 - Income Taxes - Reconciliation of Income Tax Rate (Details)	12 Months Ended
	Dec. 31, 2019	Dec. 31, 2018
Federal tax benefit at statutory rate	(21.00%)	(21.00%)
State tax, net of Federal benefit	(2.50%)	(2.90%)
Goodwill impairment		7.70%
Orphan drug credit	25.30%	(1.30%)
Change in valuation allowance	(7.50%)	15.20%
Stock compensation	8.60%
Other	0.10%
Total provision	3.00%	(2.30%)