Note 9 - Income Taxes - Deferred Tax Assets and Liabilities (Details) - USD ($)	Dec. 31, 2019	Dec. 31, 2018
Net operating loss carryforwards	$ 1,504,496	$ 5,875,074
Stock option compensation	1,381,750	2,456,410
Orphan Drug credits	81,700	2,847,803
Lease liability	63,589
Capitalized start-up costs and other	9,187,898	7,349,092
Valuation allowance	(12,051,440)	(18,091,090)
Deferred tax assets	167,993	437,289
Intangible assets	(2,223,678)	(2,223,678)
Right of use asset	(63,589)
Deferred tax liabilities	(2,287,267)	(2,223,678)
Net deferred tax liability	$ (2,119,274)	$ (1,786,389)