<SEC-DOCUMENT>0001437749-19-020753-index.html : 20191028
<SEC-HEADER>0001437749-19-020753.hdr.sgml : 20191028
<ACCEPTANCE-DATETIME>20191028165024
ACCESSION NUMBER:		0001437749-19-020753
CONFORMED SUBMISSION TYPE:	S-1/A
PUBLIC DOCUMENT COUNT:		12
FILED AS OF DATE:		20191028
DATE AS OF CHANGE:		20191028

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Diffusion Pharmaceuticals Inc.
		CENTRAL INDEX KEY:			0001053691
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				300645032
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-1/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-234234
		FILM NUMBER:		191173593

	BUSINESS ADDRESS:	
		STREET 1:		2020 AVON COURT
		STREET 2:		SUITE 4
		CITY:			CHARLOTTESVILLE
		STATE:			VA
		ZIP:			22902
		BUSINESS PHONE:		(434) 220-0718

	MAIL ADDRESS:	
		STREET 1:		2020 AVON COURT
		STREET 2:		SUITE 4
		CITY:			CHARLOTTESVILLE
		STATE:			VA
		ZIP:			22902

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	RestorGenex Corp
		DATE OF NAME CHANGE:	20140307

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Stratus Media Group, Inc
		DATE OF NAME CHANGE:	20080722

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	FERIS INTERNATIONAL, INC.
		DATE OF NAME CHANGE:	20080228
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-1/A
<SEQUENCE>1
<FILENAME>dffn20191025_s1a.htm
<DESCRIPTION>FORM S-1/A
<TEXT>
Document 1 - file: dffn20191025_s1a.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-1.1
<SEQUENCE>2
<FILENAME>ex_161321.htm
<DESCRIPTION>EXHIBIT 1.1
<TEXT>
Document 2 - file: ex_161321.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.6
<SEQUENCE>3
<FILENAME>ex_161322.htm
<DESCRIPTION>EXHIBIT 4.6
<TEXT>
Document 3 - file: ex_161322.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.7
<SEQUENCE>4
<FILENAME>ex_161323.htm
<DESCRIPTION>EXHIBIT 4.7
<TEXT>
Document 4 - file: ex_161323.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.8
<SEQUENCE>5
<FILENAME>ex_161324.htm
<DESCRIPTION>EXHIBIT 4.8
<TEXT>
Document 5 - file: ex_161324.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>6
<FILENAME>ex_161368.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
Document 6 - file: ex_161368.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>7
<FILENAME>ex_161382.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
Document 7 - file: ex_161382.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>8
<FILENAME>dffn20191014_s1img002.jpg
<TEXT>
Document 8 - file: dffn20191014_s1img002.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>9
<FILENAME>dffn20191014_s1img003.gif
<TEXT>
Document 9 - file: dffn20191014_s1img003.gif

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>10
<FILENAME>dffn20191014_s1img004.gif
<TEXT>
Document 10 - file: dffn20191014_s1img004.gif

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>11
<FILENAME>image01.jpg
<TEXT>
Document 11 - file: image01.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>12
<FILENAME>logo5_1.jpg
<TEXT>
Document 12 - file: logo5_1.jpg

</DOCUMENT>
</SEC-DOCUMENT>