<SEC-DOCUMENT>0001437749-19-010251-index.html : 20190516
<SEC-HEADER>0001437749-19-010251.hdr.sgml : 20190516
<ACCEPTANCE-DATETIME>20190516163643
ACCESSION NUMBER:		0001437749-19-010251
CONFORMED SUBMISSION TYPE:	S-3
PUBLIC DOCUMENT COUNT:		13
FILED AS OF DATE:		20190516
DATE AS OF CHANGE:		20190516

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Diffusion Pharmaceuticals Inc.
		CENTRAL INDEX KEY:			0001053691
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				300645032
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-3
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-231541
		FILM NUMBER:		19832812

	BUSINESS ADDRESS:	
		STREET 1:		2020 AVON COURT
		STREET 2:		SUITE 4
		CITY:			CHARLOTTESVILLE
		STATE:			VA
		ZIP:			22902
		BUSINESS PHONE:		(434) 220-0718

	MAIL ADDRESS:	
		STREET 1:		2020 AVON COURT
		STREET 2:		SUITE 4
		CITY:			CHARLOTTESVILLE
		STATE:			VA
		ZIP:			22902

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	RestorGenex Corp
		DATE OF NAME CHANGE:	20140307

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Stratus Media Group, Inc
		DATE OF NAME CHANGE:	20080722

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	FERIS INTERNATIONAL, INC.
		DATE OF NAME CHANGE:	20080228
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-3
<SEQUENCE>1
<FILENAME>dffn20190514_s3.htm
<DESCRIPTION>FORM S-3
<TEXT>
Document 1 - file: dffn20190514_s3.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.1
<SEQUENCE>2
<FILENAME>ex_145198.htm
<DESCRIPTION>EXHIBIT 4.1
<TEXT>
Document 2 - file: ex_145198.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.3
<SEQUENCE>3
<FILENAME>ex_144952.htm
<DESCRIPTION>EXHIBIT 4.3
<TEXT>
Document 3 - file: ex_144952.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>4
<FILENAME>ex_144951.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
Document 4 - file: ex_144951.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>5
<FILENAME>ex_145199.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
Document 5 - file: ex_145199.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>6
<FILENAME>a1.jpg
<TEXT>
Document 6 - file: a1.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>7
<FILENAME>a2.jpg
<TEXT>
Document 7 - file: a2.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>8
<FILENAME>dffn20190514_s3img003.gif
<TEXT>
Document 8 - file: dffn20190514_s3img003.gif

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>9
<FILENAME>dffn20190514_s3img004.gif
<TEXT>
Document 9 - file: dffn20190514_s3img004.gif

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>10
<FILENAME>ex01.jpg
<TEXT>
Document 10 - file: ex01.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>11
<FILENAME>ex02.jpg
<TEXT>
Document 11 - file: ex02.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>12
<FILENAME>logox.jpg
<TEXT>
Document 12 - file: logox.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>13
<FILENAME>s3img002.jpg
<TEXT>
Document 13 - file: s3img002.jpg

</DOCUMENT>
</SEC-DOCUMENT>