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Note 13 - Fair Value Measurements (Tables)
12 Months Ended
Dec. 31, 2018
Notes Tables  
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]
   
Common Stock Warrant Liability
 
Balance at January 1, 2017
  $
 
Issued in connection with the Series A convertible preferred stock
   
35,225,846
 
Change in fair value
   
(22,072,322
)
Reclassification of Series A warrants to additional paid in capital
   
(13,153,524
)
Balance at December 31, 2017
  $
 
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]
Stock price
  $
21.60
 
Exercise price
  $
33.30
 
Expected term (in years)
   
4.38
 
Risk-free interest rate
   
1.9
%
Expected volatility
   
104.1
%
Dividend yield