Note 12 - Income Taxes (Tables)

12 Months Ended

Dec. 31, 2018

Notes Tables

Schedule of Deferred Tax Assets and Liabilities [Table Text Block]

Deferred tax assets	December 31, 2018			December 31, 2017
Net operating loss carryforwards	$	5,875,074		$	5,310,628
Stock option compensation		2,456,410			2,141,973
Orphan Drug credits		2,847,803			2,537,039
Capitalized start-up costs and other		7,349,092			5,247,468
Valuation allowance		(18,091,090	)		(15,237,108	)
Net deferred tax asset	$	437,289
Deferred tax liabilities
Intangible assets		(2,223,678	)		(2,223,678	)
Net deferred tax liability	$	(1,786,389	)	$	(2,223,678	)

Summary of Operating Loss Carryforwards [Table Text Block]

Combined NOL Carryforwards:	December 31, 2018
Federal	$	22,819,972
State		22,845,568

Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]

Rate reconciliation:	December 31, 2018			December 31, 2017
Federal tax benefit at statutory rate		(21.0	)%		(34.0	)%
State tax, net of Federal benefit		(2.9	)%		(16.3	)%
Change in fair value of warrant		—	%		(126.1	)%
Change in tax rate		—	%		205.5	%
Goodwill impairment		7.7	%		—	%
Orphan drug credit		(1.3	)%		(36.0	)%
Change in valuation allowance		15.2	%		(38.8	)%
Stock compensation		—	%		1.2	%
Other		—	%		1.0	%
Total provision		(2.3	)%		(43.5	)%