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Note 4 - Property and Equipment (Tables)
12 Months Ended
Dec. 31, 2018
Notes Tables  
Property, Plant and Equipment [Table Text Block]
   
December 31,
 
   
2018
   
2017
 
Laboratory equipment
  $
182,357
    $
182,357
 
Furniture and office equipment
   
155,113
     
155,113
 
Leasehold improvements
   
430,000
     
430,000
 
Total property and equipment
   
767,470
     
767,470
 
Less: accumulated depreciation
   
(417,189
)
   
(306,818
)
Property and equipment, net
  $
350,281
    $
460,652