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Note 3 - Basis of Presentation and Summary of Significant Accounting Policies (Tables)
 12 Months Ended
Dec. 31, 2018
Notes Tables  
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
   
Year ended December 31,
  
   
2018
    
2017
  
Basic net loss per common share calculation:
                
Net loss
   $
(18,369,810
)
   $
(1,364,518
)
Accretion of Series A cumulative preferred dividends
    
(85,993
)
    
(1,252,394
)
Deemed dividend related to the make-whole provision for the conversion of Series A convertible preferred stock into common stock
    
(8,167,895
)
    
—
  
Net loss attributable to common stockholders
   $
(26,623,698
)
   $
(2,616,912
)
                 
Weighted average shares outstanding, basic
    
3,242,301
      
827,575
  
Net loss per share of common, basic
   $
(8.21
)
   $
(3.16
)
Diluted net loss per common share calculation:
                
Net loss attributable to common stockholders
    
(26,623,698
)
    
(2,616,912
)
Change in fair value of warrant liability
    
—
      
(22,072,322
)
Diluted net loss
    
(26,623,698
)
    
(24,689,234
)
Weighted average common shares outstanding, basic
    
3,242,301
      
827,575
  
Common stock equivalents arising from warrants
    
—
      
20,515
  
Common stock equivalents
    
3,242,301
      
848,090
  
Net loss per share of common stock, diluted
   $
(8.21
)
   $
(29.11
)
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
   
December 31,
  
   
2018
    
2017
  
Convertible debt
    
—
      
14,292
  
Common stock warrants
    
2,087,012
      
29,848
  
Convertible preferred stock
    
—
      
553,752
  
Stock options
    
203,736
      
170,461
  
Unvested restricted stock awards
    
—
      
204
  
     
2,290,748
      
768,557