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Note 3 - Basis of Presentation and Summary of Significant Accounting Policies - Outstanding Dilutive Securities (Details) - shares
3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Anti-dilutive securities (in shares) 34,977,433 29,471,085
Convertible Debt Securities [Member]    
Anti-dilutive securities (in shares) 214,880 766,351
Series A Convertible Preferred Stock [Member]    
Anti-dilutive securities (in shares) 12,376,329
Warrant [Member]    
Anti-dilutive securities (in shares) 31,707,223 14,016,608
Employee Stock Option [Member]    
Anti-dilutive securities (in shares) 3,053,797 2,304,132
Restricted Stock [Member]    
Anti-dilutive securities (in shares) 1,533 7,665