Note 13 - Income Taxes (Details Textual) - USD ($)	1 Months Ended	12 Months Ended
	Aug. 31, 2016	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent			34.00%	34.00%
Deferred Tax Liabilities, Net			$ 2,223,678	$ 3,279,363
Income Tax Expense (Benefit)			(1,055,685)	(364,796)
Income Tax Expense (Benefit), Continuing Operations, Adjustment of Deferred Tax (Asset) Liability			(1,100,000)
Unrecognized Tax Benefits			$ 0	0
Abandonmnet of In-Process Research and Development Intangible Asset [Member]
Income Tax Expense (Benefit)				(400,000)
In Process Research and Development Costs (IPR&D) [Member]
Deferred Tax Liabilities, Net				3,600,000
RES-440 [Member] | Research and Development Expense [Member]
Impairment of Intangible Assets (Excluding Goodwill)	$ 1,000,000			$ 1,000,000
Scenario, Forecast [Member]
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent		21.00%