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Note 9 - Commitments and Contingencies (Details Textual) - USD ($)
12 Months Ended
Sep. 27, 2016
Dec. 31, 2017
Dec. 31, 2016
Research and Development Expense   $ 5,088,621 $ 7,252,241
Litigation Settlement, Expense   2,500,000
The 2016 Convertible Notes [Member] | Settlement Agreement [Member]      
Debt Instrument, Face Amount $ 1,900,000    
Debt Instrument, Convertible, Conversion Price $ 3.50    
Litigation Settlement, Expense $ 2,500,000    
Arrangement With Clinical Research Organization [Member]      
Research and Development Expense   1,000,000  
Prepaid Research and Development Expense   800,000  
Charlottesville, Virginia [Member] | Leasehold Improvements [Member]      
Property, Plant and Equipment, Additions   400,000  
Charlottesville, Virginia [Member] | Building [Member]      
Operating Leases, Rent Expense, Net   $ 100,000 $ 66,000