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Note 10 - Convertible Preferred Stock and Stockholder's Equity (Tables)
12 Months Ended
Dec. 31, 2017
Notes Tables  
Schedule of Warrants Outstanding to Acquire Shares of Common Stock [Table Text Block]
   
Outstanding
   
Range of exercise
price per share
 
Common stock warrants issued prior to Merger
   
447,721
   
$20.00
-
$49.00
 
Common stock warrants issued in Series A
   
13,555,887
   
$2.22
 
     
14,003,608