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Note 5 - Property and Equipment (Tables)
 12 Months Ended
Dec. 31, 2017
Notes Tables  
Property, Plant and Equipment [Table Text Block]
   
December 31,
  
   
2017
    
2016
  
Laboratory equipment
   $
182,357
     $
182,357
  
Furniture and office equipment
    
155,113
      
137,290
  
Leasehold improvements
    
430,000
      
—
  
Total property and equipment
    
767,470
      
319,647
  
Less: accumulated depreciation
    
(306,818
)
    
(239,892
)
Property and equipment, net
   $
460,652
     $
79,755