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Note 3 - Basis of Presentation and Summary of Significant Accounting Policies (Tables)
 9 Months Ended
Sep. 30, 2017
Notes Tables  
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
   
Three Months Ended
September 30,
    
Nine Months Ended
September 30,
  
   
2017
    
2016
    
2017
    
2016
  
Basic net income (loss) per common share calculation:
                                
Net income (loss)
   $
5,096,856
     $
(5,436,553
)
   $
(3,154,181
)
   $
(15,465,912
)
Accretion of Series A cumulative preferred dividends
    
(366,641
)
    
—
      
(912,946
)
    
—
  
Undistributed earnings to participating securities
    
(1,838,354
)
    
—
      
—
      
—
  
Net income (loss) attributable to common stockholders
   $
2,891,861
     $
(5,436,553
)
   $
(4,067,127
)
   $
(15,465,912
)
                                 
Weighted average shares outstanding, basic
    
13,937,869
      
10,333,898
      
11,709,128
      
10,198,491
  
Net income (loss) per share of common, basic
   $
0.21
     $
(0.53
)
   $
(0.35
)
   $
(1.52
)
                                 
Diluted net income (loss) per common share calculation:
                                
Net income (loss) attributable to common stockholders
    
2,891,861
      
(5,436,553
)
    
(4,067,127
)
    
(15,465,912
)
Change in fair value of warrant liability
    
—
      
—
      
(18,909,792
)
    
 
  
Interest on convertible debt
    
28,891
      
—
      
—
      
—
  
Diluted net loss
    
2,920,752
      
(5,436,553
)
    
(22,976,919
)
    
(15,465,912
)
Weighted average common shares outstanding, basic
    
13,937,869
      
10,333,898
      
11,709,128
      
10,198,491
  
Common stock equivalents arising from stock options
    
20,608
      
—
      
—
      
—
  
Common stock equivalents arising from warrants
    
—
      
—
      
816,579
      
—
  
Common stock equivalents arising from convertible debt
    
756,376
      
—
      
—
      
—
  
Common stock equivalents
    
14,714,853
      
10,333,898
      
12,525,707
      
10,198,491
  
Net income (loss) per share of common stock, diluted
   $
0.20
     $
(0.53
)
   $
(1.83
)
   $
(1.52
)
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
   
Three Months Ended
September 30,
    
Nine Months Ended
September 30,
  
   
2017
    
2016
    
2017
    
2016
  
Convertible debt
    
—
      
749,280
      
213,879
      
749,280
  
Common stock warrants
    
14,003,608
      
460,721
      
447,721
      
460,721
  
Stock options
    
2,521,605
      
2,010,409
      
2,545,989
      
2,010,409
  
Unvested restricted stock awards
    
4,599
      
10,738
      
4,599
      
10,738
  
     
16,529,812
      
3,231,148
      
3,212,188
      
3,231,148