Note 9 - Commitments and Contingencies (Details Textual)				3 Months Ended
	Apr. 14, 2016 USD ($) shares	Sep. 15, 2014 USD ($) ft² $ / shares shares	Dec. 15, 2009 USD ($) $ / shares shares	Mar. 31, 2016 USD ($) shares	Mar. 31, 2015 USD ($)
Charlottesville, Virginia [Member] | Building [Member]
Operating Leases, Rent Expense, Net				$ 16,500	$ 16,500
Buffalo Grove [Member] | Building [Member] | Long Term Operating Lease Agreement [Member]
Area of Real Estate Property | ft²		2,900
Lessee Leasing Arrangements Operating Leases Number of Extension Options		1
Lessee Leasing Arrangements, Operating Leases, Renewal Term		3 years
Operating Leases, Number of Months from Lease Inception that Monthly Rent is Not Required to Be Paid		5
Operating Leases Monthly Rent Expense		$ 6,000
Operating Leases Annual Rent Expense		72,000
Operating Leases Annual Increase in Rent Expense for First Year		6,100
Operating Leases Annual Increase in Rent Expense For Second Year and Thereafter		$ 6,200
David G. Schmidt v. Diffusion Pharmaceuticals, LLC [Member] | Scenario, Actual [Member]
Debt Instrument, Convertible, Conversion Price | $ / shares			$ 3.50
David G. Schmidt v. Diffusion Pharmaceuticals, LLC [Member] | Plaintiff's Assertion of Entitled Conversion Price [Member]
Debt Instrument, Convertible, Conversion Price | $ / shares			$ 1
David G. Schmidt v. Diffusion Pharmaceuticals, LLC [Member] | If Conversion Price $1.00 per Unit Rather Than $3.50 per Unit [Member]
Debt Conversion, Converted Instrument, Shares Issued | shares			1,071,432.5
David G. Schmidt v. Diffusion Pharmaceuticals, LLC [Member]
Debt Conversion, Original Debt, Amount			$ 1,500,000
Loss Contingency, Damages Sought, Shares | shares				1,071,432.5
Amended David G. Schmidt V Diffusion Pharmaceuticals LLC [Member] | Plaintiff's Assertion of Entitled Conversion Price [Member]
Debt Instrument, Convertible, Conversion Price | $ / shares		$ 1
Amended David G. Schmidt V Diffusion Pharmaceuticals LLC [Member] | If Conversion Price $1.00 per Unit Rather Than $3.50 per Unit [Member] | Subsequent Event [Member]
Debt Conversion, Converted Instrument, Amount	$ 1,071,432.50
Amended David G. Schmidt V Diffusion Pharmaceuticals LLC [Member] | If Conversion Price $1.00 per Unit Rather Than $3.50 per Unit [Member]
Debt Conversion, Converted Instrument, Shares Issued | shares		1,071,432.5
Amended David G. Schmidt V Diffusion Pharmaceuticals LLC [Member] | Subsequent Event [Member]
Loss Contingency, Damages Sought, Shares | shares	1,071,432.5
Loss Contingency, Damages Sought, Proceeds From Plaintiff	$ 1,071,432.50
Amended David G. Schmidt V Diffusion Pharmaceuticals LLC [Member]
Debt Instrument, Convertible, Conversion Price | $ / shares		$ 3.50
Debt Conversion, Original Debt, Amount				$ 695,000
Debt Conversion, Converted Instrument, Amount				$ 711,495	$ 0