Costs incurred to effect a business combination which have been expensed during the period. Such costs could include business integration costs, systems integration and conversion costs, and severance and other employee-related costs.

No definition available.

Name:	us-gaap_BusinessCombinationIntegrationRelatedCosts
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

Quarterly Financial Data (Unaudited) - Acquisition and Integration Costs (Details) - USD ($) $ in Thousands	3 Months Ended						12 Months Ended
	Dec. 31, 2015	Sep. 30, 2015	Jun. 30, 2015	Mar. 31, 2015	Dec. 31, 2014	Sep. 30, 2014	Dec. 31, 2015	Dec. 31, 2014
Quarterly Financial Data (Unaudited)
Acquisition and integration related costs	$ 2,991	$ 2,865	$ 423	$ 119			$ 3,546	$ 895
BVF/CSNK
Quarterly Financial Data (Unaudited)
Acquisition and integration related costs					$ 609	$ 234