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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
CASH FLOWS FROM OPERATING ACTIVITIES:    
Net loss $ (56,473) $ (44,149)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 22,427 23,633
Non-cash interest expense 4,409 8,601
Accretion of discount on investments (891) 761
Stock-based compensation 42,761 36,608
Deferred income taxes (704) (13,988)
Unrealized foreign exchange (gain) loss (419) 5,616
Non-cash changes in the fair value of contingent consideration 12,260 5,631
Other (19) 662
Changes in operating assets and liabilities:    
Accounts receivable, net (51,690) (26,257)
Inventory 1,735 10,843
Other current assets 10,112 2,924
Other assets 2,220 (1,099)
Accounts payable and accrued liabilities (42,070) (51,887)
Other long-term liabilities 1,474 (408)
Net cash used in operating activities (54,868) (42,509)
CASH FLOWS FROM INVESTING ACTIVITIES:    
Purchases of property, plant and equipment (28,756) (30,164)
Maturities and sales of investments 219,894 104,462
Purchases of available-for-sale securities (239,843) (145,933)
Other (1,774) (99)
Net cash used in investing activities (50,479) (71,734)
CASH FLOWS FROM FINANCING ACTIVITIES:    
Proceeds from exercises of awards under equity incentive plans 5,798 13,134
Taxes paid related to net share settlement of equity awards (30,105) (22,899)
Other (674) 0
Net cash used in financing activities (24,981) (9,765)
Effect of exchange rate changes on cash 715 (40)
NET DECREASE IN CASH AND CASH EQUIVALENTS (129,613) (124,048)
Cash and cash equivalents:    
Beginning of period 493,982 [1] 598,028
End of period 364,369 473,980
SUPPLEMENTAL CASH FLOW DISCLOSURES:    
Cash paid for income taxes 906 11,731
Cash paid for interest 1,483 1,528
SUPPLEMENTAL CASH FLOW DISCLOSURES FOR NON CASH INVESTING AND FINANCING ACTIVITIES:    
Decrease in accounts payable and accrued liabilities related to fixed assets $ (3,502) $ (11,367)
[1] December 31, 2018 balances were derived from the audited Consolidated Financial Statements included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2018, filed with the SEC on February 28, 2019.