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Summary of Significant Accounting Policies - Additional Information (Detail)
3 Months Ended 6 Months Ended 12 Months Ended
Dec. 31, 2016
USD ($)
Dec. 31, 2016
USD ($)
Dec. 31, 2016
USD ($)
Segment
Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Significant Accounting Policies [Line Items]          
Goodwill impairment $ 0        
Impairment charge   $ 0 $ 599,118,000 $ 198,700,000 $ 0
Number of operating business segment | Segment     1    
Aldurazyme | Minimum          
Significant Accounting Policies [Line Items]          
Payment received as percentage of net product sales 39.50% 39.50% 39.50%    
Aldurazyme | Maximum          
Significant Accounting Policies [Line Items]          
Payment received as percentage of net product sales 50.00% 50.00% 50.00%