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Collaborative Agreements - Additional Information (Detail)
shares in Millions
12 Months Ended
Dec. 31, 2016
USD ($)
Country
Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Dec. 31, 2012
USD ($)
shares
Oct. 31, 2012
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]          
Termination of collaborative agreement prior to written notice in number of days 90 days        
Licensing arrangement, convertible promissory note received $ 0 $ 3,326,000 $ 52,288,000    
Royalties on net product sales         7.00%
Royalties on net product sales         10.00%
Catalyst Pharmaceutical Partners, Inc.          
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]          
Licensing arrangement, convertible promissory note received       $ 5,000,000  
Licensing arrangement, shares received upon conversion promissory note | shares       6.7  
Accounts receivable $ 0        
Merck Serono          
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]          
Transfer of marketing authorizations in remaining countries | Country 4