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Acquisitions - Additional Information (Detail) - USD ($)
$ / shares in Units, $ in Thousands
12 Months Ended
Jan. 29, 2015
Mar. 10, 2014
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Business Acquisition [Line Items]          
Business acquisitions, net of cash acquired     $ 538,392   $ 9,875
Contingent consideration payable     85,600    
Net gain recognized due to early termination of lease and realization of remaining balance in deferred rent and reversal of asset retirement obligation       $ 10,092  
Prosensa Holding N.V          
Business Acquisition [Line Items]          
Business acquisitions, net of cash acquired $ 751,500        
Business combination transaction costs 9,700   7,000 2,700  
Business acquisition, cash paid 680,100        
Contractual right, amount 160,000        
Acquired IPR&D 772,808        
Prosensa Holding N.V | Kyndrisa and Prosensa's other primary product candidates          
Business Acquisition [Line Items]          
Acquired IPR&D 731,800        
Prosensa Holding N.V | PRO 044          
Business Acquisition [Line Items]          
Acquired IPR&D 16,900        
Prosensa Holding N.V | PRO-045          
Business Acquisition [Line Items]          
Acquired IPR&D $ 24,100        
Prosensa Holding N.V | CVRs          
Business Acquisition [Line Items]          
Contractual right, share price $ 4.14        
Contingent consideration payable $ 71,400        
Prosensa Holding N.V | Prosensa Shares          
Business Acquisition [Line Items]          
Business acquisition, cash paid $ 620,700        
Approximate percentage of shares tendered at closing of initial offering 96.80%        
Prosensa Holding N.V | Remaining Prosensa share holders          
Business Acquisition [Line Items]          
Business acquisition, cash paid $ 20,800        
Prosensa Holding N.V | Vested options for Prosensa shares          
Business Acquisition [Line Items]          
Business acquisition, cash paid $ 38,600        
San Rafael Corporate Center          
Business Acquisition [Line Items]          
Business acquisition, cash paid   $ 116,500      
Net gain recognized due to early termination of lease and realization of remaining balance in deferred rent and reversal of asset retirement obligation       8,800  
San Rafael Corporate Center | Royalty, License and Other Revenues          
Business Acquisition [Line Items]          
Tenant revenue, other real estate     2,700 4,000  
Amortization expense     $ 1,200 1,800  
San Rafael Corporate Center | Selling, General and Administrative          
Business Acquisition [Line Items]          
Business combination transaction costs       300  
Net gain recognized due to early termination of lease and realization of remaining balance in deferred rent and reversal of asset retirement obligation       2,700  
San Rafael Corporate Center | Research and Development          
Business Acquisition [Line Items]          
Net gain recognized due to early termination of lease and realization of remaining balance in deferred rent and reversal of asset retirement obligation       $ 6,100