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Segment Information by Product Revenue (Detail) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Revenue from External Customer [Line Items]      
Net product revenues $ 884,522 $ 738,416 $ 538,360
Vimizim      
Revenue from External Customer [Line Items]      
Net product revenues 228,147 77,319 85
Naglazyme      
Revenue from External Customer [Line Items]      
Net product revenues 303,090 334,447 271,244
Kuvan      
Revenue from External Customer [Line Items]      
Net product revenues 239,336 202,987 167,422
Aldurazyme      
Revenue from External Customer [Line Items]      
Net product revenues 97,912 105,616 83,545
Firdapse      
Revenue from External Customer [Line Items]      
Net product revenues $ 16,037 $ 18,047 $ 16,064