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CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
shares in Thousands, $ in Thousands
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
REVENUES:      
Total revenues $ 1,846,275 $ 1,860,455 $ 1,704,048
OPERATING EXPENSES:      
Cost of sales 470,515 524,272 359,466
Research and development 628,793 628,116 715,007
Selling, general and administrative 759,375 737,669 680,924
Intangible asset amortization and contingent consideration 69,933 66,658 74,108
Gain on sale of nonfinancial assets 0 (59,495) (25,000)
Total operating expenses 1,928,616 1,897,220 1,804,505
LOSS FROM OPERATIONS (82,341) (36,765) (100,457)
Interest income 10,482 16,610 22,748
Interest expense (15,337) (29,309) (23,460)
Other income, net 11,846 7,142 6,358
LOSS BEFORE INCOME TAXES (75,350) (42,322) (94,811)
Benefit from income taxes (11,270) (901,422) (70,963)
NET INCOME (LOSS) $ (64,080) $ 859,100 $ (23,848)
NET INCOME (LOSS) PER SHARE, BASIC (in usd per share) $ (0.35) $ 4.75 $ (0.13)
NET INCOME (LOSS) PER SHARE, DILUTED (in usd per share) $ (0.35) $ 4.53 $ (0.13)
Weighted average common shares outstanding, basic (in shares) 182,852 180,804 179,039
Weighted average common shares outstanding, diluted (in shares) 182,852 191,678 179,039
Product      
REVENUES:      
Total revenues $ 1,783,498 $ 1,805,861 $ 1,661,043
Royalty and Other Revenues      
REVENUES:      
Total revenues $ 62,777 $ 54,594 $ 43,005