PROPERTY, PLANT AND EQUIPMENT |
PROPERTY, PLANT AND EQUIPMENT Property, Plant and Equipment, Net, consisted of the following: | | | | | | | | | | | | | December 31, | | 2020 | | 2019 | Building and improvements | $ | 761,560 | | | $ | 725,906 | | Manufacturing and laboratory equipment | 414,439 | | | 366,951 | | Computer hardware and software | 189,740 | | | 167,554 | | Land | 90,418 | | | 90,418 | | Leasehold improvements | 55,134 | | | 51,324 | | Furniture and equipment | 40,223 | | | 38,569 | | Land improvements | 7,412 | | | 7,349 | | Construction-in-progress | 109,140 | | | 111,897 | | | 1,668,066 | | | 1,559,968 | | Accumulated depreciation | (635,595) | | | (549,100) | | Total property, plant and equipment, net | $ | 1,032,471 | | | $ | 1,010,868 | |
The construction-in-progress balance primarily included costs related to significant in-progress projects at the Company's facilities in Marin County, California, and Shanbally, Ireland. | | | | | | | | | | | | | | | | | | | Years Ended December 31, | | 2020 | | 2019 | | 2018 | Depreciation expense | $ | 88,169 | | | $ | 89,285 | | | $ | 90,375 | | Depreciation capitalized into inventory | $ | 44,492 | | | $ | 37,481 | | | $ | 25,227 | |
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