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PROPERTY, PLANT AND EQUIPMENT
12 Months Ended
Dec. 31, 2020
Property, Plant and Equipment [Abstract]  
PROPERTY, PLANT AND EQUIPMENT PROPERTY, PLANT AND EQUIPMENT
Property, Plant and Equipment, Net, consisted of the following:
December 31,
20202019
Building and improvements$761,560 $725,906 
Manufacturing and laboratory equipment414,439 366,951 
Computer hardware and software189,740 167,554 
Land90,418 90,418 
Leasehold improvements55,134 51,324 
Furniture and equipment40,223 38,569 
Land improvements7,412 7,349 
Construction-in-progress109,140 111,897 
1,668,066 1,559,968 
Accumulated depreciation(635,595)(549,100)
Total property, plant and equipment, net$1,032,471 $1,010,868 
The construction-in-progress balance primarily included costs related to significant in-progress projects at the Company's facilities in Marin County, California, and Shanbally, Ireland.
Years Ended December 31,
202020192018
Depreciation expense$88,169 $89,285 $90,375 
Depreciation capitalized into inventory$44,492 $37,481 $25,227