Rule 424(b)(2) Prospectus Supplement
                                                    Registration No. 333-48800


PROSPECTUS SUPPLEMENT No. 3
TO PROSPECTUS DATED October 3, 2002




                                 265,816 Shares

                          BioMarin Pharmaceutical Inc.

                                  Common Stock
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         This Prospectus Supplement supplements information contained in that
certain Prospectus of BioMarin Pharmaceutical Inc. dated October 3, 2002
relating to the potential sale and issuance from time to time of up to 2,500,000
shares of BioMarin common stock. This Prospectus Supplement is not complete
without, and may not be delivered or utilized except in connection with, the
Prospectus, including any amendments or supplements thereto. This Prospectus
Supplement is incorporated by reference into the Prospectus. You should read
this Prospectus Supplement and the accompanying Prospectus carefully before you
invest. Both documents contain information you should consider carefully before
making your investment decision.


         See "Risk Factors" beginning on page 4 of the Prospectus to read about
risks that you should consider before buying shares of our common stock.

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         You should rely only on the information provided or incorporated by
reference in this Prospectus Supplement and the Prospectus. We have not
authorized anyone else to provide you with different information. You should not
assume that the information in this Prospectus Supplement is accurate as of any
date other than the date on the front of this Prospectus Supplement.

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         NEITHER THE SECURITIES EXCHANGE COMMISSION NOR ANY STATE SECURITIES
COMMISSION HAS APPROVED OR DISAPPROVED OF THE SECURITIES OR PASSED UPON THE
ACCURACY OR ADEQUACY OF THIS PROSPECTUS. ANY REPRESENTATION TO THE CONTRARY IS A
CRIMINAL OFFENSE.

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             The date of this Prospectus Supplement is April 7, 2003






                                TABLE OF CONTENTS


PROSPECTUS SUPPLEMENT

Plan of Distribution........................................................S-1

PROSPECTUS

Summary.......................................................................1

The Offering..................................................................3

Risk Factors..................................................................4

Forward Looking Statements...................................................16

Use of Proceeds..............................................................17

Plan of Distribution.........................................................18

Legal Matters................................................................20

Experts......................................................................20







         The following information supplements the information set forth in the
Prospectus.



                              PLAN OF DISTRIBUTION



         On April 7, 2003, we will issue and sell 265,816 shares of our common
stock to Acqua Wellington North American Equities Fund, Ltd. pursuant to the
Prospectus as supplemented by this Prospectus Supplement and pursuant to the
terms of the common stock purchase agreement entered into between Acqua
Wellington and us on August 15, 2001, as amended. The common stock will be
purchased at a negotiated purchase price of $11.40 per share. We will pay
Reedland Capital Partners, an Institutional Division of Financial West Group, a
fee of $30,303 in consideration of placement agent services related to this
purchase by Acqua Wellington. We will not pay any other compensation in
conjunction with the sale of these shares of our common stock. See "Plan of
Distribution" beginning on page 18 of the Prospectus.


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