UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C.  20549
SCHEDULE 13G
Under the Securities Exchange Act of 1934
					(Amendment No. _2_)*

Response Genetics, Inc.
                  _____________________________________________
       (Name of Issuer)

Common Stock, .01 Par Value
                 _______________________________________________
(Title of Class of Securities)

76123U105
                 _________________________________________________
(CUSIP Number)


		with a copy to:
Austin W. Marxe		Allen B. Levithan, Esq.
527 Madison Avenue, Suite 2600		Lowenstein Sandler PC
New York, New York 10022		65 Livingston Avenue
			Roseland, New Jersey 07068
			(973) 597-2406
(Name, Address and Telephone Number of Person
Authorized to Receive Notices and Communications)

December 31, 2013
(Date of Event which Requires Filing of this Statement)


Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:

	____	Rule 13d-1(b)
	_x__	Rule 13d-1(c)
	____	Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which
would alter disclosures provided in a prior cover page.
The information required on the remainder of this cover page shall not be
deemed
 to be ?filed? for the purpose of Section 18 of the Securities Exchange Act
of
 1934 (?Act?) or otherwise subject to the liabilities of that section of the
Act
 but shall be subject to all other provisions of the Act (however, see the
Notes).



Cusip No. 76123U105       13G                           Page 2 of 6 Pages
1.Names of Reporting Persons.  I.R.S. Identification Nos. of above persons
(entities only):

	Austin W. Marxe, David M. Greenhouse and Adam C. Stettner


	2.	Check the Appropriate Box if a Member of a Group (See
Instructions):
	(a)	[    ]	 	Not Applicable
	(b)	[    ]

	3.	SEC Use Only

	4.	Source of Funds (See Instructions):  00

	5.	Check if Disclosure of Legal Proceedings Is Required Pursuant to
Items 2(d) or 2(e):
				Not Applicable

	6.	Citizenship or Place of Organization:	    United States

	Number of	7.	Sole Voting Power:	0
	Shares Beneficially	8.	Shared Voting Power:	2,679,179*
	Owned by
	Each Reporting	9.	Sole Dispositive Power:	0
	Person With	10.	Shared Dispositive Power: 2,679,179*___

	11.	Aggregate Amount Beneficially Owned by Each Reporting Person:
            2,679,179*

	12.	Check if the Aggregate Amount in Row (11) Excludes Certain Shares
		(See Instructions):		               Not Applicable

	13.	Percent of Class Represented by Amount in Row (11):     6.9%*

	14.	Type of Reporting Person (See Instructions):       IA, IN


* This is a joint filing by Austin W. Marxe (?Marxe?), David M. Greenhouse
(?Greenhouse?) and Adam C. Stettner (?Stettner?).  Marxe, Greenhouse and
Stettner share sole voting and investment power over 693,393 Common Shares
owned by Special Situations Cayman Fund, L.P., 929,852 Common Shares owned by
Special Situations Life Sciences Fund, L.P. and 1,055,934 Common Shares owned
by Special Situations Fund III QP, LP.. See Items 2 and 4 of this Schedule
for additional information.


								Page 3 of 6 Pages
Item 1.	Security and Issuer:
	(a) Response Genetics, Inc.
	(b) 1640 Marengo Street, Los Angeles, CA 90033

Item 2. (a)	Name of Person Filing:
	The persons filing this report are Austin W. Marxe (?Marxe?),
David M. Greenhouse (?Greenhouse?) and Adam C. Stettner (?Stettner?), who are
members of SSCayman LLC (?SSCay?), the general partner of Special Situations
Cayman Fund, L.P. (?Cayman?).  Marxe, Greenhouse and Stettner are controlling
principals of AWM Investment Company, Inc. (?AWM?), the general partner of
MGP Advisers Limited Partnership (?MGP?), the general partner of Special
Situations Fund III QP, L.P. (?SSFQP?).  Marxe, Greenhouse and Stettner are
also members of LS Advisers L.L.C. (?LS?), the general partner of Special
Situations Life Sciences Fund, L.P. (?SSLS?). AWM serves as the investment
adviser to Cayman, SSFQP and SSLS. The principal business of each Fund is to
invest in equity and equity-related securities and other securities of any
kind or nature.



             (b) Address of Principal Business Office or, if none, Residence:

	The principal business address for Marxe, Greenhouse and Stettner
is 527 Madison Avenue, Suite 2600, New York, NY  10022.



              (c) Citizenship:

       	           Austin W. Marxe, David M. Greenhouse and Adam C.
Stettner are United States citizens.

              (d) Title of Class of Securities:  Common Stock
	              (e) CUSIP Number:  76123U105.

Item 3.     If this statement is filed pursuant to $240.13d-1(b) or 240.13d-
2(b), check whether
            the person filing is a:    Not Applicable

(a) ( )	Broker or Dealer registered under section 15 of the Act;
(b) ( )	Bank as defined in section 3(a) (6) of the Act;
(c) ( )	Insurance Company as defined in section 3(a) (19) of the Act;
(d) ( )	Investment Company registered under section 8 of the Investment
Company Act of 1940;
(e) ( )	An Investment Adviser in accordance with $240.13d
		-1(b)(I)(ii)(E);
(f) ( )	An employee benefit plan or endowment fund in accordance with
$240.13d-1(b)(I)(ii)(F);


								Page 4 of 6 Pages

(g) ( )	A parent holding company or control person in accordance with
$240.13d-
	1(b)(1)(ii)(G);
(h) ( ) 	A savings association as defined in Section 3(b) of the Federal
Deposit Insurance

	Act;
(i) ( ) 	A church plan that is excluded from the definition of an
investment company under section 3(c)(14) of the Investment
Company Act of 1940;
(j) ( )  	Group, in accordance with $240.13d-1(b)(1)(ii)(J).


Item 4.       Ownership:

	 (a) Amount Beneficially Owned:  Messrs. Marxe, Greenhouse and Stettner
beneficially own a total of 2,679,179 Common Shares.  This amount includes
693,393 Common Shares owned by Cayman, 929,852 Common shares owned by SSLS
and 1,055,934 Common Shares owned by SSFQP.

	(b) Percent of Class:  Messrs. Marxe, Greenhouse and Stettner
beneficially own 6.9% of the outstanding shares, of which Cayman owns 1.8% of
the outstanding shares, SSLS owns 2.4% of the outstanding shares and SSFQP
owns 2.7% of the outstanding shares.

	(c) Number of Shares as to which the person has:

		(i)	Sole power to vote or to direct the vote:  0

		(ii)	Shared power to vote or to direct the vote:  2,679,179

		(iii)	Sole power to dispose or to direct the disposition of:  0

(iv)	Shared power to dispose or to direct the disposition of:
2,679,179


Item 5. Ownership of Five Percent or Less of a Class:  If this statement is
being filed to report the fact that as of the date hereof the reporting
person has ceased to be the beneficial owner of more that five percent of the
class of securities, check the following __.

Item 6.Ownership of More than Five Percent on Behalf of Another Person:  Not
Applicable.

Item 7. Identification and Classification of the Subsidiary Which Acquired
the Security being Reported on By the Parent Holding Company:  Not
Applicable.

Item 8. Identification and Classification of Members of the Group:  Not
applicable

Item 9. Notices of Dissolution of Group:  Not applicable.







									Page 5 of 6 Pages

Item 10.Certification:

	By signing below I certify that, to the best of my knowledge and
belief, the securities
referred to above were acquired and are held in the ordinary course of
business and were not
acquired and are not held for the purpose of or with the effect of changing
or influencing the
control of the issuer of the securities and were not acquired and are not
held in connection with
or as a participant in any transaction having that purpose or effect.



SIGNATURE


	After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete
and correct.


Dated: February 7, 2014


				/s/ Austin W. Marxe
				AUSTIN W. MARXE



				/s/David M Greenhouse
				DAVID M. GREENHOUSE



	/s/Adam C. Stettner
	ADAM C. STETTNER













Attention:  Intentional misstatements or omissions of fact constitute Federal
criminal violations (See 18 U.S.C. 1001).







       								Page 6 of 6 Pages



JOINT FILING AGREEMENT


	Austin W. Marxe, David M. Greenhouse and Adam C. Stettner hereby agree
that the Schedule 13G to which this agreement is attached is filed on behalf
of each of them.



	/s/_Austin W. Marxe
Austin W. Marxe



	/s/_David M. Greenhouse
David M. Greenhouse



	/s/ Adam C. Stettner
	Adam C. Stettner
-6-

S5313/1
1319328.02