Exhibit 107

Calculation of Filing Fee Tables

Form S-3

(Form Type)

CymaBay Therapeutics, Inc.

(Exact name of Registrant as specified in its charter)

Table 1: Newly Registered and Carry Forward Securities

Security Type

Security Class Title

Fee Calculation or Carry Forward Rule

Amount Registered

Proposed Maximum Offering Price Per Unit

Maximum Aggregate Offering Price

Fee Rate

Amount of Registration Fee

Carry Forward Form Type

Carry Forward File Number

Carry Forward Initial effective date

Filing Fee Previously Paid In Connection with Unsold Securities to be Carried Forward

Newly Registered Securities

Fees to Be Paid

Equity

Common Stock, $0.0001 par value per share

Rule 457(o) and Rule 457(r)

4,642,857(1)

$0.0001 (2)

$465.00

$0.00011020

$0.06

Total Offering Amounts

$465.00

$0.06

Total Fees Previously Paid

—

Total Fee Offsets

—

Net Fee Due

$0.06

(1) Shares of common stock issuable upon the exercise of pre-funded warrants. Pursuant to Rule 416(a) promulgated under the Securities Act of 1933, as amended (the “Securities Act”), this Registration Statement shall also cover any additional shares of Registrant’s common stock that become issuable under the pre-funded warrants set forth herein by reason of any stock dividend, stock split, recapitalization, or other similar transaction effected that results in an increase to the number of outstanding shares of Registrant’s common stock, as applicable.

(2) Reflects the exercise price per share of the pre-funded warrants.