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We consent to the incorporation by reference in the Registration Statements of Rockwell Medical Inc. and Subsidiaries (the “Company”) on Form’s S-3 (Registration No.’s 333-259923, 333-228437, 333-160710, 333-148601 and 333-135872) and Form’s S-8 (Registration No.’s 333-238889, 333-237229, 333-227365, 333-204653, 333-196752, 333-189586, 333-182043, 333-176524, 333-169003, 333-160135, 333-153046, 333-146817, 333-135896, 333-126627 and 333-66791) of our report dated April 8, 2022 with respect to our audits of the consolidated financial statements of the Company as of December 31, 2021 and 2020, and for each of the two years in the period ended December 31, 2021, which report is included in this Annual Report on Form 10-K of the Company for the year ended December 31, 2021.