Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the incorporation by reference in Registration Statements on Forms S-3 (Registration No.’s. 333-135872 and 333-148601) and Forms S-8 (Registration No.’s 333-66791, 333-126627, 333-135896, 333-146817, and 333-153046) of Rockwell Medical Technologies, Inc. of our reports dated March 12, 2009 on the consolidated financial statements of Rockwell Medical Technologies, Inc. as of and for the years ended December 31, 2008 and 2007 and on the effectiveness of the Company’s internal control over financial reporting as of December 31, 2008, appearing in the Annual Report on Form 10-K of Rockwell Medical Technologies, Inc. for the year ended December 31, 2008.

/s/ Plante & Moran, PLLC

Auburn Hills, Michigan
March 12, 2009