Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the incorporation by reference in this Registration Statement of Rockwell Medical Technologies, Inc. on Form S-3 of our report dated March 23, 2007 on the consolidated financial statements of Rockwell Medical Technologies, Inc. appearing in the Annual Report on Form 10-KSB of Rockwell Medical Technologies, Inc. as of and for the year ended December 31, 2006 and to the reference to us under the heading “Experts” in the Prospectus, which is part of this Registration Statement.

/s/ Plante & Moran, PLLC

Auburn Hills, Michigan

January 9, 2008