FILED PURSUANT TO
                                                                  RULE 424(b)(3)
                                                             FILE NO. 333-127048

                           PROSPECTUS SUPPLEMENT DATED
                        JANUARY 19, 2006 TO PROSPECTUS
                             DATED OCTOBER 17, 2005


                                  INTRODUCTION


     This Prospectus Supplement dated January 19, 2006 to the Prospectus dated
October 17, 2005 (the "Prospectus") relates to an offer (the "Offer") by
Rockwell Medical Technologies, Inc. ("we", "us" or the "Company") to sell up to
3,625,000 common shares issuable upon exercise of 3,625,000 Common Share
Purchase Warrants with an exercise price of $3.90 per share ("New Warrants").

     If you have not received the Prospectus, the Supplement to the Prospectus
dated November 14, 2005 and related materials or if you have any questions about
the Offer, please contact your broker or other securities intermediary, or the
transfer agent for the Offer, American Stock Trust & Transfer Company, toll-free
at (877) 248-6417 or at (718) 921-8317.

                           COMPLETION OF TENDER OFFER

     On December 6, 2005, we announced that we had completed our offer to
exchange up to 3,625,000 New Warrants for 3,625,000 outstanding Common Share
Purchase Warrants with an exercise price of $4.50 per share ("Old Warrants").
Warrant holders exchanged 3,270,303 Old Warrants for an equal number of New
Warrants. Both the Old Warrants and New Warrants expire on January 26, 2006. The
New Warrants have an exercise price of $3.90 per common share.

                   LEASE AGREEMENT FOR SOUTH CAROLINA FACILITY

     On February 23, 2005, we entered into a short term lease agreement for a
61,000 square foot facility in Hodges, South Carolina. Monthly rent for the
facility was $17,500. On February 23, 2005 we also entered into a lease
agreement with another entity for certain equipment at that facility. The
monthly lease cost was $12,500. That lease agreement permitted the purchase of
certain equipment at a specified price with the lease payments made during the
lease period as consideration for such purchase election.

     Both of these lease agreements terminated on December 9, 2005 at which time
we exercised our option to acquire certain equipment. We also entered into a
tri-party agreement to extend the lease of the facility and the use of certain
tangible personal property in the facility on a month to month basis effective
December 9, 2005. Monthly rent for the building and equipment is $37,500.

                         AMENDMENT TO LICENSE AGREEMENT

     On January 15, 2006, we entered into an amending agreement with Charak LLC
("Charak") and Dr. Ajay Gupta (the "Amendment"), which amended the existing
licensing agreement among the parties dated January 7, 2002. Pursuant to the
Amendment, Charak granted us an exclusive license to make, manufacture and sell
a water-soluble vitamin and carnitine mixture for dialysis patients which is
covered by a U.S. patent. The patent covers the method for preventing and
correcting vitamin deficiency in both hemodialysis and peritoneal dialysis
patients with renal failure. Prior to marketing the product, we will have to
obtain US Food & Drug Administration (FDA) approval.

     There is no material relationship between us and any of the parties to the
Amendment other than as described above.

                          SECURITY OWNERSHIP OF CERTAIN
                        BENEFICIAL OWNERS AND MANAGEMENT

     On December 15, 2005, we issued stock options under the Company's 1997
Stock Option Plan to our directors and officers. In addition, on December 15,
2005, we accelerated the vesting of all outstanding unvested options granted
under the Company's 1997 Stock Option Plan to December 31, 2005. We accelerated
the vesting of the unvested options in order to avoid recognizing an expense in
our financial statements under the Financial Accounting Standards Board's
Statement No. 123R, which, after January 1, 2006, would have required us to
recognize compensation expense equal to the grant date fair value of such
unvested options over their vesting period. The following table sets forth, as
of January 15, 2006, certain information concerning the common shares
beneficially owned by each director, the chief executive officer and the chief
financial officer of the Company, by all executive officers and directors of the
Company as a group, and by each shareholder that is a beneficial owner of more
than 5% of the outstanding common shares:



                                                                                              PERCENTAGE
                                                       AMOUNT AND NATURE                   BENEFICIALLY OWNED
                                                         OF BENEFICIAL     BEFORE THE EXERCISE     AFTER THE EXERCISE OF
                                                         OWNERSHIP (1)     OF NEW WARRANTS (2)        NEW WARRANTS (3)
                                                         -------------     -------------------     --------------------
                                                                                             
NAME
Robert L. Chioini(4).......................               2,472,516(8)            23.0%(8)                17.6%(8)
Kenneth L. Holt(5).........................                 173,000(9)             1.9%(9)                 1.4%(9)
Ronald D. Boyd(6)..........................                160,000(10)            1.8%(10)                1.3%(10)
Patrick J. Bagley(7).......................                202,950(11)            2.3%(11)                1.7%(11)
Thomas E. Klema(4).........................                890,004(12)            9.2%(12)                6.9%(12)
All directors and executive officers as a
group (5 Persons) .........................              3,898,470(13)           32.5%(13)               25.5%(13)
Revocable Trust of Robert S. Brown ........                713,254(14)            8.0%(14)                5.9%(14)
4565 Chamberlain Drive
East China, MI 48054
Patricia Xirinachs.........................                630,000(15)            7.1%(15)                5.2%(15)





                                                                                           PERCENTAGE
                                                                                       BENEFICIALLY OWNED
                                                       AMOUNT AND NATURE   ---------------------------------------------
                                                         OF BENEFICIAL     BEFORE THE EXERCISE     AFTER THE EXERCISE OF
                                                         OWNERSHIP (1)     OF NEW WARRANTS (2)        NEW WARRANTS (3)
                                                       -----------------   -------------------     ---------------------
                                                                                          
NAME

1325 Franklin Ave
Suite 250
Garden City, NY 11530
Perkins Capital Management.................                445,500(16)            5.0%(16)                3.7%(16)
730 East Lake Drive
Wayzata, Minnesota 55391

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(1)   Unless otherwise indicated, each person has sole investment and voting
      power with respect to the shares indicated, subject to community property
      laws, where applicable. For purposes of computing the percentage of
      outstanding shares held by each person or group of persons named above as
      of the date of the table, any security which such person or group of
      persons has the right to acquire within 60 days after such date is deemed
      to be outstanding for the purpose of computing the percentage ownership
      for such person or persons, but is not deemed to be outstanding for the
      purpose of computing the percentage ownership of any other person.

(2)   Based on 8,886,948 common shares outstanding as of December 31, 2005.

(3)   Based on 12,157,251 common shares outstanding, assuming all 3,270,303 New
      Warrants are exercised.

(4)   Address is c/o the Company, 30142 Wixom Road, Wixom, Michigan 48393.

(5)   Address is c/o Charleston Renal Care, LLC, 109 Greenland Drive, South
      Carolina 29445.

(6)   Address is 1912 West Hampton Point Drive, Statesboro, Georgia 30458.

(7)   Address is c/o Bagley and Langan, P.L.L.C., 4540 Highland Road, Waterford,
      Michigan 48328.

(8)   Includes 1,868,000 common shares that Mr. Chioini has the right to acquire
      within 60 days of the date of this Prospectus Supplement pursuant to the
      Company's 1997 Stock Option Plan.

(9)   Includes 160,000 common shares that Mr. Holt has the right to acquire
      within 60 days of the date of this Prospectus Supplement pursuant to the
      Company's 1997 Stock Option Plan and 13,000 common shares that Mr. Holt
      has the right to acquire within 60 days of the date of this Prospectus
      Supplement pursuant to New Warrants.

(10)  Includes 160,000 common shares that Mr. Boyd has the right to acquire
      within 60 days of the date of this Prospectus Supplement pursuant to the
      Company's 1997 Stock Option Plan.

(11)  Includes 25,000 common shares that Mr. Bagley has the right to acquire
      within 60 days of the date of this Prospectus Supplement pursuant to the
      Company's 1997 Stock Option Plan; 34,700 common shares owned by Mr.
      Bagley's wife and 8,000 shares owned by Bagley and Langan, P.L.L.C., of
      which Mr. Bagley is the Senior Partner and sole owner. Also includes
      62,500 shares and 7,000 shares that Mr. Bagley's wife and Bagley and
      Langan, P.L.L.C., respectively, have the right to acquire within 60 days
      of the date of this Prospectus Supplement pursuant to New Warrants.

(12)  Includes 815,500 common shares that Mr. Klema has the right to acquire
      within 60 days of the date of this Prospectus Supplement pursuant to the
      Company's 1997 Stock Option Plan.

(13)  Includes the common shares described in notes (8) through (12) above.

(14)  This information is based upon conversations with the trustee of the
      Revocable Trust of Robert S. Brown and includes 713,254 common shares
      beneficially owned by Robert S. Brown.

(15)  Includes 20,000 common shares that Mrs. Xirinachs' husband, Michael J.
      Xirinachs, has the right to acquire within 60 days of the date of this
      Prospectus Supplement, pursuant to the Company's 1997 Stock Option Plan
      and 5,000 common shares which he owns. This information is based on
      conversations between the Company and Michael J. Xirinachs and information
      provided by the Company's transfer agent.

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(16)  Based on Schedule 13F filing as of December 31, 2004.


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