EXHIBIT 32.1


                    CERTIFICATIONS OF CHIEF EXECUTIVE OFFICER
                           AND CHIEF FINANCIAL OFFICER
                                   PURSUANT TO
                             18 U.S.C. SECTION 1350,
                             AS ADOPTED PURSUANT TO
                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002


         In connection with the Annual Report of Rockwell Medical Technologies,
Inc. (the "Company") on Form 10-KSB for the year ending December 31, 2004 as
filed with the Securities and Exchange Commission on the date hereof (the
"Periodic Report"), I, Robert L. Chioini, Chief Executive Officer of the Company
and I, Thomas E. Klema, Chief Financial Officer of the Company, each certify,
pursuant to 18 U.S.C. ss.1350, as adopted pursuant tO ss.906 of the
Sarbanes-Oxley Act of 2002, that:

         1.       the Periodic Report fully complies with the requirements of
                  Section 13(a) or 15(d) of the Securities Exchange Act of 1934;
                  and

         2.       the information contained in the Periodic Report fairly
                  presents, in all material respects, the financial condition
                  and results of operations of the Company.



Dated:  March 22, 2005                    /s/ Robert L. Chioini
                                          -----------------------------------
                                                   Robert L. Chioini
                                                   Chief Executive Officer



Dated:  March 22, 2005                    /s/ Thomas E. Klema
                                          -------------------
                                                   Thomas E. Klema
                                                   Chief Financial Officer



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