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Stockholders' Equity - Schedule of Share-based Compensation Stock Options Plan (Details) - Stock Options [Member] - USD ($)
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Number of Shares Subject to Issuance, Outstanding 235,478 40,936
Number of Shares Subject to Issuance, Granted 1,689,882 203,622
Number of Shares Subject to Issuance, Forfeited or expired (23,749) (9,080)
Number of Shares Subject to Issuance, Exercised (313)
Number of Shares Subject to Issuance, Outstanding 1,901,298 235,478
Number of Shares Subject to Issuance, Exercisable 495,518  
Weighted-average Exercise Price, Outstanding $ 5.95 $ 18.48
Weighted-average Exercise Price, Granted 1.18 4.31
Weighted-average Exercise Price, Forfeited or expired 25.82 $ 9.63
Weighted-average Exercise Price, Exercised 3.12
Weighted-average Exercise Price, Outstanding 1.46 $ 5.95
Weighted-average Exercise Price, Exercisable $ 1.63  
Weighted-average Remaining Contractual Term, Outstanding Beginning 4 years 5 months 9 days 2 years 5 months 1 day
Weighted-average Remaining Contractual Term, Outstanding Ending 4 years 6 months 4 days 4 years 5 months 9 days
Weighted-average Remaining Contractual Term, Exercisable 4 years 5 months 5 days  
Outstanding-Aggregate Intrinsic Value $ 12,100
Exercisable-Aggregate Intrinsic Value