Exhibit 32.1

CERTIFICATION PURSUANT TO

18 U.S.C. SECTION 1350,

AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

I, Mathew N. Hulett, and I, Christine Chambers, each certify to the best of our knowledge, based upon a review of the Annual Report on Form 10-K for the year ended March 31, 2023 (the “Report”) of PetMed Express, Inc. (the “Registrant”), that:

(1)the Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and

(2)the information contained in the Report, fairly presents, in all material respects, the financial condition and results of operations of the Registrant.

Date: May 23, 2023
By:	/s/ Mathew N. Hulett
Mathew N. Hulett
Chief Executive Officer and President
By:	/s/ Christine Chambers
Christine Chambers
Chief Financial Officer and Treasurer