Exhibit H

                             JOINT FILING STATEMENT

     The undersigned hereby agree as follows:

     (i) Each of them is individually eligible to use the Schedule 13D to which
this Exhibit is attached, and such Schedule 13D is filed on behalf of each of
them; and

     (ii) Each of them is responsible for the timely filing of such Schedule 13D
and any amendments thereto, and for the completeness and accuracy of the
information concerning such person contained therein; but none of them is
responsible for the completeness or accuracy of the information concerning the
other persons making the filing, unless such person knows or has reason to
believe that such information is inaccurate.

Date: August 30, 2005

                                        GREAT POINT PARTNERS LLC


                                        Signature: /s/ Dr. Jeffrey R. Jay, M.D.
                                                   -----------------------------
                                                   By Dr. Jeffrey R. Jay, M.D.,
                                                      as senior managing member


                                        BIOMEDICAL VALUE FUND L.P.


                                        Signature: /s/ Dr. Jeffrey R. Jay, M.D.
                                                   -----------------------------
                                                   By Great Point Partners, LLC,
                                                      as investment manager,

                                                   By Dr. Jeffrey R. Jay, M.D.,
                                                      as senior managing member


                                        BIOMEDICAL OFFSHORE VALUE FUND, LTD.


                                        Signature: /s/ Dr. Jeffrey R. Jay, M.D.
                                                   -----------------------------
                                                   By Great Point Partners, LLC,
                                                      as investment manager,

                                                   By Dr. Jeffrey R. Jay, M.D.,
                                                      as senior managing member


                                        DR. JEFFREY R. JAY, M.D.


                                        Signature: /s/ Dr. Jeffrey R. Jay, M.D.
                                                   -----------------------------